4446-73-5

Basic information

• Product Name: 1-(biphenyl-4-yl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
• Synonyms: 1,3,5-triazine-2,4-diamine, 1-[1,1'-biphenyl]-4-yl-1,6-dihydro-6,6-dimethyl-
• CAS NO: 4446-73-5
• Molecular Formula: C₁₇H₁₉N₅
• Molecular Weight: 293.3663
• Mol File: 4446-73-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 478.6°C at 760 mmHg
• Flash Point: 243.2°C
• Density: 1.23g/cm³
• Vapor Pressure: 2.55E-09mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 1-(biphenyl-4-yl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(biphenyl-4-yl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine(4446-73-5)
• EPA Substance Registry System: 1-(biphenyl-4-yl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine(4446-73-5)

Safety Data

• Hazardous Substances Data: 4446-73-5(Hazardous Substances Data)

Usage

Derivative

Thalidomide

Pharmaceutical Drug

Yes

Treatments

Multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma

Mechanism of Action

Slows the growth of cancer cells and stimulates the immune system to attack and destroy cancer cells

Properties

Potent inhibitor of angiogenesis, anti-inflammatory

Importance

Used in the treatment of various cancers and inflammatory diseases

Structure

Consists of a biphenyl group attached to a 1,6-dihydro-1,3,5-triazine-2,4-diamine core

Molecular Weight

310.37 g/mol

Appearance

White to off-white crystalline powder

Solubility

Soluble in dimethyl sulfoxide (DMSO), slightly soluble in ethanol and methanol, and practically insoluble in water

Melting Point

210-215°C

CAS Registry Number

110535-04-5

Manufacturer

Celgene Corporation (a subsidiary of Bristol-Myers Squibb)

Approval

Approved by the US FDA in 2005 for the treatment of multiple myeloma

Dosage Forms

Available as capsules for oral administration