4446-91-7 Usage
Description
(3-chloro-1-methoxypropyl)benzene, also known as 1-Chloro-3-methoxy-2-propylbenzene, is a chemical compound belonging to the alkylbenzenes family. It is an aromatic hydrocarbon with a benzene ring substituted with one or more alkyl groups. This colorless to pale yellow liquid has a molecular formula of C9H11ClO and a molecular weight of 168.63 g/mol.
Uses
Used in Pharmaceutical Synthesis:
(3-chloro-1-methoxypropyl)benzene is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of compounds with potential therapeutic properties in medical treatments.
Used in Agrochemical Synthesis:
In addition to pharmaceuticals, (3-chloro-1-methoxypropyl)benzene is also utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of products for agricultural applications.
Safety Precautions:
Due to its potential hazards, (3-chloro-1-methoxypropyl)benzene should be handled with care, and proper safety measures should be taken when working with this chemical to ensure the safety of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 4446-91-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,4 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4446-91:
(6*4)+(5*4)+(4*4)+(3*6)+(2*9)+(1*1)=97
97 % 10 = 7
So 4446-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13ClO/c1-12-10(7-8-11)9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3
4446-91-7Relevant articles and documents
Chemoselective and direct functionalization of methyl benzyl ethers and unsymmetrical dibenzyl ethers by using iron trichloride
Sawama, Yoshinari,Goto, Ryota,Nagata, Saori,Shishido, Yuko,Monguchi, Yasunari,Sajiki, Hironao
supporting information, p. 2631 - 2636 (2014/03/21)
Methyl and benzyl ethers are widely utilized as protected alcohols due to their chemical stability, such as the low reactivity of the methoxy and benzyloxy groups as leaving groups under nucleophilic conditions. We have established the direct azidation of chemically stable methyl and benzyl ethers derived from secondary and tertiary benzyl alcohols. The present azidation chemoselectively proceeds at the secondary or tertiary benzylic positions of methyl benzyl ethers or unsymmetrical dibenzyl ethers and is also applicable to direct allylation, alkynylation, and cyanation reactions, as well as the azidation. The present methodologies provide not only a novel chemoselectivity but also the advantage of shortened synthetic steps, due to the direct process without the deprotection of the methyl and benzyl ethers. Ethers exchanged: Methyl and benzyl ethers are chemically stable and generally tolerant under nucleophilic substitution conditions. Iron-catalyzed direct functionalizations (e.g., azidation, allylation, alkynylation, and cyanation) of methyl and benzyl ethers derived from secondary and tertiary benzyl alcohols were established with excellent regioselectivities (see scheme; PG: protecting group; Bn: benzyl; Nu: nucleophile; TMS: trimethylsilyl). Copyright