444659-43-2Relevant articles and documents
Synthesis and profile of SCH351591, a novel PDE4 inhibitor
Billah, Motasim,Cooper, Nicola,Cuss, Francis,Davenport, Richard J.,Dyke, Hazel J.,Egan, Robert,Ganguly, Ashit,Gowers, Lewis,Hannah, Duncan R.,Haughan, Alan F.,Kendall, Hannah J.,Lowe, Christopher,Minnicozzi, Michael,Montana, John G.,Naylor, Robert,Oxford, Janet,Peake, Joanna C.,Piwinski, John J.,Runcie, Karen A.,Sabin, Verity,Sharpe, Andrew,Shih, Neng-Yang,Warneck, Julie B.H.
, p. 1621 - 1623 (2002)
The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS
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Page/Page column 24, (2010/02/11)
In one embodiment, the present application discloses a process for making the compound of the formula: