444666-41-5

Basic information

• Product Name: 1-(4-METHOXY-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: 1-(4-METHOXY-PYRIDIN-2-YL)-PIPERAZINE;1-(4-Ethoxy-pyridin-2-yl)-piperazine;1-(4-methoxypyridin-2-yl)piperazine hydrochloride
• CAS NO: 444666-41-5
• Molecular Formula: C₁₀H₁₅N₃O
• Molecular Weight: 193.25
• Mol File: 444666-41-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 369.954°C at 760 mmHg
• Flash Point: 177.542°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: 2-8°C
• PKA: 9.73±0.27(Predicted)
• CAS DataBase Reference: 1-(4-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(444666-41-5)
• EPA Substance Registry System: 1-(4-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(444666-41-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 444666-41-5(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxy-pyridin-2-yl)-piperazine, also known as MPP, is a chemical compound that belongs to the piperazine class of organic compounds. It is a heterocyclic amine that contains a piperazine ring and a pyridine ring with a methoxy group attached to the 4-position of the pyridine ring. MPP is often used as a building block in the synthesis of pharmaceutical drugs, particularly those with central nervous system activities. It has also been studied for its potential role as an antipsychotic and anxiolytic agent. The compound is of interest to researchers and pharmaceutical companies for its potential therapeutic applications.

InChI:InChI=1/C10H15N3O/c1-14-9-2-3-12-10(8-9)13-6-4-11-5-7-13/h2-3,8,11H,4-7H2,1H3

Upstream product

• 110-85-0 piperazine 
• 17228-69-2 2-chloro-4-methoxy-pyridine 

Downstream Products

• 1443769-41-2 2-(1,4-bis-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(4-(4-methoxypyridin-2-yl)piperazin-1-yl)ethanone 
• 1447723-84-3 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(4-methoxy-pyridin-2-yl)-piperazin-1-yl)-ethanone 

Relevant articles and documents

SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS

This invention relates to compounds of formula (I), their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents

The invention relates to arylpiperazine-benzoylamide derivatives of formula (I) wherein A, X1, X2, n and R1 to R10 are defined as in claim 1, which are suitable for the treatment of diseases characterized by exc

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.