444902-32-3

Basic information

• Product Name: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-
• Synonyms: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-;5-Amino-2-chloro-3-iodopyridine;6-Chloro-5-iodo-pyridin-3-ylaMine;6-chloro-5-iodopyridin-3-aMine
• CAS NO: 444902-32-3
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.454
• Product Categories: amine| alkyl chloride| alkyl Iodine
• Mol File: 444902-32-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 115-125°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: /
• Density: 2.139 g/cm³
• PKA: 0.97±0.10(Predicted)
• CAS DataBase Reference: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(444902-32-3)
• EPA Substance Registry System: 3-PYRIDINAMINE, 6-CHLORO-5-IODO-(444902-32-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-50
• Safety Statements: 26-39-61
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 444902-32-3(Hazardous Substances Data)

Usage

General Description

3-Pyridinamine, 6-chloro-5-iodo- is a chemical compound with the molecular formula C5H4ClIN2. It is a derivative of pyridine and contains both chlorine and iodine atoms. 3-PYRIDINAMINE, 6-CHLORO-5-IODO- is commonly used in organic synthesis and can be a building block for various pharmaceuticals and agrochemicals. Its unique structure and properties make it useful in the development of new drugs and other important chemical products. Additionally, it may also be used as a reagent in chemical reactions and as a research tool in academic laboratories.

Upstream product

• 25391-60-0 2-chloro-3-iodo-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 25391-58-6 2-hydroxy-3-iodo-5-nitropyridine 
• 7439-89-6 iron 

Downstream Products

• 444902-34-5 2-chloro-5-hydroxy-3-iodopyridine 

Relevant articles and documents

Synthesis and in-vivo evaluation of [11C]p-PVP-MEMA as a PET radioligand for imaging nicotinic receptors

Within the class of (4-pyridinyl)vinylpyridines developed by Abbott laboratories as potent neuronal nicotinic acetylcholine receptor ligands, p-PVP-MEMA ({(R)-2-[6-chloro-5-((E)-2-pyridin-4-ylvinyl)pyridin-3-yloxy]-1- methylethyl}methylamine) is the lead compound of a novel series that do not display the traditional nicotinic-like pyrrole-ring but still possessing high subnanomolar affinity (Ki 0.077 nm?displacement of [ 3H](?)cytisine from whole rat brain synaptic membranes). In the present study, p-PVP-MEMA and its nor-derivative ({(R)-2-[6-chloro-5-((E)-2- pyridin-4-ylvinyl)pyridin-3-yloxy]-1-methylethyl}methylamine) as precursor for labelling with the short-lived positron-emitter carbon-11 (T1/2 20.4 min) were synthesized in 10 chemical steps from 2-hydroxy-5-nitropyridine and Boc-d-alanine. N-Alkylation of nor-p-PVP-MEMA with [11C]methyl iodide afforded [11C]p-PVP-MEMA (>98% radiochemically pure, specific activity of 86.4 GBq ?mol?1) in 2% (non-decay corrected and non-optimized) radiochemical yield, in 34 min (including HPLC purification and formulation). Preliminary positron emission tomography (PET) results obtained in a Papio hamadryas baboon showed that [11C]p-PVP-MEMA is not a suitable PET-radioligand. CSIRO 2008.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.