445-14-7 Usage
Description
2-AMINO-4-CHLOROBENZOTRIFLUORIDE, also known as 2-amino-4-chloro-α,α,α-trifluorotoluene, is an organic compound with a molecular structure that features a chlorine atom and an amino group attached to a benzene ring with three fluorine atoms. It is a significant molecule in the field of biochemistry and pharmaceuticals due to its unique properties and potential applications.
Uses
Used in Biochemical Research:
2-AMINO-4-CHLOROBENZOTRIFLUORIDE is used as a potent activator for the histone acetyltransferase (HAT) of p300. This application is crucial in the study of epigenetic regulation, gene expression, and cellular processes, as HATs play a vital role in these areas.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-AMINO-4-CHLOROBENZOTRIFLUORIDE is used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique chemical properties make it a valuable building block for the development of new therapeutic agents.
Used in Drug Delivery Systems:
Similar to gallotannin, 2-AMINO-4-CHLOROBENZOTRIFLUORIDE can also be employed in the development of novel drug delivery systems. These systems aim to improve the bioavailability, delivery, and therapeutic outcomes of drugs that utilize 2-AMINO-4-CHLOROBENZOTRIFLUORIDE as a key component.
Check Digit Verification of cas no
The CAS Registry Mumber 445-14-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 445-14:
(5*4)+(4*4)+(3*5)+(2*1)+(1*4)=57
57 % 10 = 7
So 445-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClF3N/c8-4-1-2-5(6(12)3-4)7(9,10)11/h1-3H,12H2
445-14-7Relevant articles and documents
Deoxofluorination of (Hetero)aromatic Acids
Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.
, p. 3110 - 3124 (2020/03/23)
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.
Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors
Tordeux, Marc,Langlois, Bernard,Wakselman, Claude
, p. 2293 - 2299 (2007/10/02)
Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.
