445-38-5

Basic information

• Product Name: 1-(3-chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one
• Synonyms: 1-(3-chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one
• CAS NO: 445-38-5
• Molecular Weight: 188.586
• Mol File: 445-38-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(3-chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one(445-38-5)
• EPA Substance Registry System: 1-(3-chloro-5-fluoro-2-hydroxyphenyl)ethan-1-one(445-38-5)

Safety Data

• Hazardous Substances Data: 445-38-5(Hazardous Substances Data)

Usage

Appearance

Yellow-orange pigment

Source

Found in turmeric, a spice and food coloring

Medicinal properties

a. Anti-inflammatory
b. Antioxidant
c. Anti-cancer

Potential health applications

a. Arthritis treatment
b. Diabetes management
c. Cardiovascular disease prevention

Research status

Promising results in preclinical and clinical studies

Field of interest

Medicine and pharmacology

Upstream product

• 1996-41-4 2-chloro-4-fluorophenol 
• 108-24-7 acetic anhydride 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 

Downstream Products

• 16108-84-2 1-(4-Acetamino-benzolsulfonylhydrazono)-1-(5-fluor-3-chlor-2-hydroxy-phenyl)-ethan 
• 1245737-91-0 8-chloro-6-fluoro-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 

Relevant articles and documents

COMPOUND USED AS KINASE INHIBITOR AND APPLICATION THEREOF

Provided is the compound represented by formula I, or tautomer thereof, or meso thereof, racemate thereof, and mixture of meso and racemate thereof, or enantiomer thereof, diastereomer, and mixture of enantiomer and diastereomer, or pharmaceutically acceptable salt thereof, or deuterate thereof. The compound of formula I can be used as a kinase inhibitor, as a drug for the treatment of ROS1, NTRK, ALK and other kinase-mediated diseases.

FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.