4450-98-0 Usage
Description
Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (EBPC) is a potent and selective inhibitor of the human aldose reductase enzyme (AKR1B1), which plays a crucial role in the polyol pathway responsible for the conversion of glucose into sorbitol. It also functions as a highly efficient PGF2α synthase in response to interleukin-1β. EBPC has been found to be effective in enhancing the sensitivity of HeLa cells to chemotherapeutic drugs and regulating glucose metabolism, making it a promising compound for various applications in the medical field.
Uses
Used in Anticancer Applications:
Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate is used as an anticancer agent for enhancing the sensitivity of HeLa cervical carcinoma cells to chemotherapeutic drugs such as doxorubicin and cisplatin. By regulating glucose metabolism and inhibiting aldose reductase, EBPC improves the cytotoxic effects of these anticancer agents, potentially leading to better treatment outcomes for patients with cervical cancer.
Used in Pharmaceutical Industry:
Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate is used as a highly specific aldose reductase inhibitor for the development of novel therapeutic strategies targeting diabetes-related complications. Increased aldose reductase expression has been associated with such complications, and EBPC's ability to inhibit this enzyme may contribute to the development of more effective treatments for diabetes.
Used in Endometrial Cell Research:
In the field of endometrial cell research, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate is used as an inhibitor of prostaglandin F2α (PGF2α) and PGE2 production. With an EC50 value of 10 μM, EBPC has the potential to be utilized in the development of treatments for conditions related to abnormal prostaglandin production in human endometrial cells.
Check Digit Verification of cas no
The CAS Registry Mumber 4450-98-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,5 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4450-98:
(6*4)+(5*4)+(4*5)+(3*0)+(2*9)+(1*8)=90
90 % 10 = 0
So 4450-98-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,18H,2,8-9H2,1H3/b14-11-
4450-98-0Relevant articles and documents
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold
Coumar, Mohane Selvaraj,Wu, Jian-Sung,Leou, Jiun-Shyang,Tan, Uan-Kang,Chang, Chung-Yu,Chang, Teng-Yuan,Lin, Wen-Hsing,Hsu, John T.-A.,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang
, p. 1623 - 1627 (2008/12/21)
Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.
