445006-90-6

Basic information

• Product Name: Cyclohexanecarbonitrile, 1-[(2-iodophenyl)methyl]-
• CAS NO: 445006-90-6
• Molecular Formula: C14H16IN
• Molecular Weight: 325.192
• Mol File: 445006-90-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarbonitrile, 1-[(2-iodophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonitrile, 1-[(2-iodophenyl)methyl]-(445006-90-6)
• EPA Substance Registry System: Cyclohexanecarbonitrile, 1-[(2-iodophenyl)methyl]-(445006-90-6)

Safety Data

• Hazardous Substances Data: 445006-90-6(Hazardous Substances Data)

Upstream product

• 40400-13-3 2-Iodobenzyl bromide 
• 766-05-2 cyclohexane carbonitrile 

Downstream Products

• 104367-54-6 1-benzylcyclohexanecarbonitrile 
• 26673-29-0 spiro[cyclohexane-1,2'-indan]-1'-one 
• 927675-32-9 1-(2-{3-[(3-phenylprop-2-yn-1-yl)oxy]prop-1-yn-1-yl}benzyl)cyclohexanecarbonitrile 
• 927675-34-1 1-{2-[7-(2-thienyl)hepta-1,6-diyn-1-yl]benzyl}cyclohexanecarbonitrile 

Relevant articles and documents

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.