445222-85-5

Basic information

• Product Name: ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1'-(2-ethoxy-2-oxoethyl)-5,6,7,8-tetrahydrospiro[4H-chromene-4,3'-(2'H)-indole]-3-carboxylate
• Synonyms: ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1'-(2-ethoxy-2-oxoethyl)-5,6,7,8-tetrahydrospiro[4H-chromene-4,3'-(2'H)-indole]-3-carboxylate
• CAS NO: 445222-85-5
• Molecular Formula: C25H28N2O7
• Molecular Weight: 468.49902
• Mol File: 445222-85-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1'-(2-ethoxy-2-oxoethyl)-5,6,7,8-tetrahydrospiro[4H-chromene-4,3'-(2'H)-indole]-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1'-(2-ethoxy-2-oxoethyl)-5,6,7,8-tetrahydrospiro[4H-chromene-4,3'-(2'H)-indole]-3-carboxylate(445222-85-5)
• EPA Substance Registry System: ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1'-(2-ethoxy-2-oxoethyl)-5,6,7,8-tetrahydrospiro[4H-chromene-4,3'-(2'H)-indole]-3-carboxylate(445222-85-5)

Safety Data

• Hazardous Substances Data: 445222-85-5(Hazardous Substances Data)

Upstream product

• 41042-21-1 (1-ethoxycarbonylmethyl)isatin 
• 126-81-8 dimedone 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant articles and documents

Monoclinic zirconia nanoparticle-catalyzed regioselective synthesis of some novel substituted spirooxindoles through one-pot multicomponent reaction in a ball mill: A step toward green and sustainable chemistry

A highly efficient, green as well as atom economical protocol for the synthesis of substituted spirooxindoles from m-ZrO2 NPs catalyzed multicomponent reaction of isatin derivatives with ethyl cyanoacetate and 1,3-dicarbonyl compounds in a ball mill has been established. Because of the simple and readily available starting materials, easy operation, and high bioactivity of substituted spirooxindoles, this strategy can be broadly applied to medicinal chemistry. The recyclability of the m-ZrO2 Nps catalyst is another emphasis of proposed methodology.

Immobilization of 1,4-diazabicyclo[2.2.2]octane (DABCO) over mesoporous silica SBA-15: An efficient approach for the synthesis of functionalized spirochromenes

Immobilized 1,4-diazabicyclo[2.2.2]octane (DABCO) over mesoporous silica SBA-15 has been found to be an efficient heterogeneous base catalyst for the synthesis of biologically active functionalized spirochromene derivatives via three-component reaction of