445303-67-3

Basic information

• Product Name: 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester
• Synonyms: 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester;1,3,2-Dioxaborolane, 2-[3-fluoro-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-;2-(3-Fluoro-4-(trifluoroMethyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;3-Fluoro-4-(trifluoroMethyl)benzeneboronic acid pinacol ester, 96%
• CAS NO: 445303-67-3
• Molecular Formula: C₁₃H₁₅BF₄O₂
• Molecular Weight: 290.06
• Product Categories: Aryl;Organoborons
• Mol File: 445303-67-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /Solid
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester(445303-67-3)
• EPA Substance Registry System: 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester(445303-67-3)

Safety Data

• Hazardous Substances Data: 445303-67-3(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester is a chemical compound that belongs to the class of boronic acid pinacol esters. It is a fluorinated organic compound that contains a boronic acid functional group, which is commonly used in organic synthesis and medicinal chemistry. 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester is a valuable building block for the preparation of pharmaceuticals, agrochemicals, and materials. The presence of both fluorine and boron atoms in its structure makes it highly useful for a range of synthetic applications, and it is often employed as a reagent in cross-coupling reactions to form carbon-carbon bonds. Its unique properties and versatility in chemical reactions make it a valuable tool for researchers and chemists in the development of new molecules and compounds.

Upstream product

• 142808-15-9 4-bromo-2-fluoro-1-(trifluoromethyl)benzene 
• 73183-34-3 bis(pinacol)diborane 
• 392-85-8 1-fluoro-2-trifluoromethylbenzene 

Downstream Products

• 1110771-95-3 ethyl 5-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylisoxazole-3-carboxylate 
• 1255041-78-1 C₁₂H₁₀F₄O₂ 
• 1354818-79-3 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 
• 1354819-06-9 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate 
• 219581-07-4 3-fluoro-4-(trifluoromethyl)phenol 
• 1235407-47-2 5-fluoro-2-iodo-4-(trifluoromethyl)phenol 
• 1235407-46-1 5-fluoro-2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol 
• 1417332-63-8 methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trifluoromethyl)-phenyl)picolinate 
• 1533422-43-3 C₁₃H₁₂F₇NO₄S 

Relevant articles and documents

Ligand-Enabled, Iridium-Catalyzed ortho-Borylation of Fluoroarenes

A terpyridine derivative and an iridium complex catalyze the C-H borylation of a stoichiometric amount of a fluoroarene with high ortho-selectivity and tolerance of functional groups such as bromide, chloride, ester, ketone, amine, and in situ-borylated hydroxyl. Complex drug molecules such as haloperidol can be selectively borylated ortho to the F atom. The terpyridine ligand undergoes rollover cyclometalation to produce an N,N,C-coordinated iridium complex, which may either selectively borylate the fluoroarene by itself or undergo reductive elimination to produce a borylated ligand.

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

Fluorine-controlled C-H borylation of arenes catalyzed by a PSiN-pincer platinum complex

An efficient, regioselective synthesis of fluorine-substituted arylboronic esters was achieved through fluorine-controlled C-H borylation of arenes with diboron catalyzed by a PSiN-platinum complex. The promising utility of the PSiN-platinum catalyst and its unique regioselectivity were demonstrated for the first time, which would complement the well-developed Ir-catalyzed C-H borylation.