445424-01-1

Basic information

• Product Name: Benzene, 1-(cyclopropylethynyl)-3-methoxy-
• CAS NO: 445424-01-1
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Mol File: 445424-01-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(cyclopropylethynyl)-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(cyclopropylethynyl)-3-methoxy-(445424-01-1)
• EPA Substance Registry System: Benzene, 1-(cyclopropylethynyl)-3-methoxy-(445424-01-1)

Safety Data

• Hazardous Substances Data: 445424-01-1(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 81166-84-9 (2-cyclopropylethynyl)trimethylsilane 
• 6746-94-7 Cyclopropylacetylene 
• 766-85-8 3-methoxy-1-iodobenzene 

Downstream Products

• 1263053-80-0 cyclobutenyl(3-methoxyphenyl)methanone 

Relevant articles and documents

CsF-Mediated in Situ Desilylation of TMS-Alkynes for Sonogashira Reaction

A practical and mild set of conditions for the Sonogashira reaction utilizing CsF-mediated in situ TMS-alkyne desilylation followed by Sonogashira coupling has been developed for the synthesis of a variety of alkynyl benzenes and heteroarenes in good to excellent yields. This methodology demonstrates excellent functional group tolerance and simple purification, which allows large-scale industrial applications. This one-pot protocol enables a high-yielding Sonogashira coupling with volatile alkynes by avoiding challenging isolation of free alkynes.