446-50-4

Basic information

• Product Name: 1-fluoro-2-(iodomethyl)benzene
• Synonyms: 1-fluoro-2-(iodomethyl)benzene
• CAS NO: 446-50-4
• Molecular Weight: 236.028
• Mol File: 446-50-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-fluoro-2-(iodomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-2-(iodomethyl)benzene(446-50-4)
• EPA Substance Registry System: 1-fluoro-2-(iodomethyl)benzene(446-50-4)

Safety Data

• Hazardous Substances Data: 446-50-4(Hazardous Substances Data)

Upstream product

• 95-52-3 2-Fluorotoluene 
• 446-52-6 2-Fluorobenzaldehyde 
• 446-51-5 2-fluorobenzyl alcohol 
• 345-35-7 2-fluorobenzyl chloride 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 1554260-87-5 C₁₆H₁₃F 
• 326-62-5 2-fluorophenyl acetonitrile 
• 1311411-79-6 C₂₄H₂₇BrFNO₄ 
• 1311411-98-9 C₃₀H₃₄FN₂O₆^(1-)*Na⁽¹⁺⁾ 
• 1311411-97-8 C₂₄H₂₈BrFNO₅^(1-)*Li⁽¹⁺⁾ 
• 1311411-93-4 C₄₀H₄₆F₂N₄O₆ 
• 1311411-91-2 C₄₆H₆₀F₂N₄O₆Si 
• 1311411-90-1 C₃₉H₅₁BrF₂N₂O₆Si 
• 1311411-88-7 C₃₅H₃₉FN₄O₄ 
• 1311411-86-5 C₄₀H₄₇FN₄O₆ 
• 1311411-84-3 C₃₃H₃₈BrFN₂O₆ 
• 1311411-82-1 C₃₀H₄₃BrFNO₅Si 
• 1311411-80-9 C₂₄H₂₉BrFNO₅ 
• 1311409-28-5 C₄₃H₅₂FN₅O₇ 

Relevant articles and documents

Synthetic method of prasugrel intermediate o-fluorophenylacetic acid

The invention discloses a synthetic method of prasugrel intermediate o-fluorophenylacetic acid. The reaction process comprises the steps that (1) 2-fluorotoluene, N-halosuccinimide, an initiator and asolvent S1 are mixed uniformly, protective gas is introduced, the pressure is controlled to be 1.5-2 atmospheric pressure, the temperature is controlled to be 90-120 DEG C, stirring reaction is conducted for 1-2 h, and a mixture M1 is obtained; (2) a catalyst is mixed uniformly with a cyanide aqueous solution, the pressure is controlled to be 2-3 atmospheric pressure, the temperature is controlled to be 80-100 DEG C, the mixture M1 is added into a reaction system, then conditions are maintained to continue the reaction for 1-2 h, still standing and layering are conducted, organic phase is collected and concentrated to 1/2 of the original volume, and a mixture M2 is obtained; and (3) the mixture M2 is mixed uniformly with hydrochloric acid and glacial acetic acid, refluxing is conducted for 40-55 min, the mixture is poured into crushed ice after cooling, a solvent S2 is added for extraction, and after the organic phase is dried by a drying agent, a product is obtained by concentratingby a rotary evaporator. According to the synthetic method, safety and reliability are achieved, the production cost is low, three wastes are basically avoided, and the synthetic method is suitable forindustrial production.

Deoxycyanamidation of Alcohols with N-Cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS)

The first one-pot deoxycyanamidation of alcohols has been developed using N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as both a sulfonyl transfer reagent and a cyanamide source, accessing a diverse range of tertiary cyanamides in excellent isolated yields. This approach exploits the underdeveloped desulfonylative (N-S bond cleavage) reactivity pathway of NCTS, which is more commonly employed for electrophilic C- and N-cyanation processes.

Manganese(III)-mediated selective diphenylphosphinoyl radical reaction of 1,4-diaryl-1-butynes for the synthesis of 2-phosphinoylated 3,4- dihydronaphathalenes

A diphenylphosphinoyl radical-initiated sequential reaction of 1,4-diaryl-1-butynes and analogues is developed for the synthesis of 2-phosphinoylated 3,4-dihydronaphathalenes and related compounds.