446-96-8

Basic information

• Product Name: Acetamide, N-ethyl-2,2,2-trifluoro-N-phenyl-
• CAS NO: 446-96-8
• Molecular Formula: C10H10F3NO
• Molecular Weight: 217.191
• Mol File: 446-96-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, N-ethyl-2,2,2-trifluoro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-ethyl-2,2,2-trifluoro-N-phenyl-(446-96-8)
• EPA Substance Registry System: Acetamide, N-ethyl-2,2,2-trifluoro-N-phenyl-(446-96-8)

Safety Data

• Hazardous Substances Data: 446-96-8(Hazardous Substances Data)

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 103-69-5 N-ethyl-N-phenylamine 
• 62-53-3 aniline 
• 74-96-4 ethyl bromide 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 76-05-1 trifluoroacetic acid 
• 54962-15-1 lithium N-ethyl-N-phenylamide 
• 51599-76-9 N-trifluoroacetoxy succinimide 
• 183266-61-7 1-(trifluoroacetyl)benzotriazole 
• 155094-66-9 2-Chloro-N-ethyl-2-fluoro-N-phenyl-acetamide 

Downstream Products

• 110972-20-8 N-(1-cyano-2,2,2-trifluoroethyl)-N-ethylaniline 
• 110972-16-2 N-Ethyl-N-(1-methoxy-2,2,2-trifluoroethyl)aniline 
• 55204-36-9 N-ethyl-N-(2,2,2-trifluoro-ethyl)-aniline 

Relevant articles and documents

Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.

A convenient trifluoroacetylation reagent: N- (trifluoroacetyl)succinimide

N-(Trifluoroacetyl)succinimide, easily prepared from trifluoroacetic anhydride and succinimide forms a novel, convenient trifluoroacetylating reagent. It trifluoroacetylates alcohols, phenols and mines, to generate trifluoroacetate esters, and trifluoroacetamides in excellent yields with very efficient work up procedures.

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.