4461-26-1Relevant articles and documents
Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines
Liang, Helong,Li, Ganzhong,Zhang, Lei,Wang, Gefei,Song, Mingyu,Li, Heng,Yuan, Bingxin
supporting information, p. 5821 - 5825 (2021/08/01)
A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1,3,5-triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to react with amidine, introducing two substituents to the 1,3,5-triazinone ring with a low production cost and a simple workup procedure. The scalability of this method was demonstrated by translating a small-scale procedure to a multi-kilogram-scale synthesis. Chlorination and a further coupling reaction with various nucleophiles could provide unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.
Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine
Shaw-Ponter, Sue,Mills, Gail,Robertson, Mark,Bostwick, Roy D.,Hardy, George W.,Young, Robert J.
, p. 1867 - 1870 (2007/10/03)
The use of the 3-O-(N-acyl)carbamoyl directing groups in the synthesis of the potent anti-Herpes virus agent 2′-deoxy-5-ethyl-4′-thio-D-uridine is described. This includes details of experiments to optimise the carbamate substitution and a multi-gram exemplification of the key steps.
Synthesis of 6-aminopenicillanic acid derivatives. I. 6-(Acylureido) penicillanates and some related compounds.
Naito,Nakagawa,Okumura,Konishi,Kawaguchi
, p. 145 - 157 (2007/10/05)
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