446878-27-9

Basic information

• Product Name: Carbamic acid, [(1S)-2-[(6-aminohexyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 446878-27-9
• Molecular Formula: C20H33N3O3
• Molecular Weight: 363.5
• Mol File: 446878-27-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-[(6-aminohexyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-[(6-aminohexyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(446878-27-9)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-[(6-aminohexyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(446878-27-9)

Safety Data

• Hazardous Substances Data: 446878-27-9(Hazardous Substances Data)

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 3674-06-4 Boc-Phe-ONSu 
• 166410-31-7 N-fluorenylmethoxycarboxnyl-N'-tert-butoxycarbonylhexanediamine 
• 166410-37-3 Ν¹-(9-fluorenylmethyloxycarbonyl)-1,6-hexamethylenediamine 

Downstream Products

• 872172-30-0 [2-{3-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-hexylcarbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 846569-22-0 N'-(6-(benzyloxycarbonylmethyl-1,3-ureido)hexyl)-N-tert-Boc-L-phenylalaninamide 

Relevant articles and documents

Efficient monoacylation of symmetrical secondary alkanediamines and synthesis of unsymmetrical diacylated alkanediamines. A new L-proline-based organocatalyst

A simple procedure was developed for the monoacylation of several unprotected alkanediamines with carboxylic acids by using PyBOP-HOBt as coupling agent in the presence of DIEA at room temperature. Yields were moderate with primary alkanediamines and good to excellent with linear or cyclic secondary ones. To illustrate the utility of these monoacylated products, six unsymmetrical diacylated alkanediamines were synthesized. In addition, one of these compounds was evaluated as organocatalyst in an asymmetric aldol reaction. R' R' NHR O R N O R N PyBOP, HOBt PyBOP, HOBt DIEA, DMF DIEA, DMF NHR NHR O N O 10 equiv O R 11 exemples R' R = H, alkyl R'' OH 67-95% yield R'' OH 6 exemples

The chirality of dendrimer-based supramolecular complexes

Boc-protected L-phenylalanine has been connected to a spacer-armed ureido-acetic acid derivative, which can form multiple supramolecular complexes with urea-adamantyl modified poly(propylene imine) dendrimers in chloroform. Complexes of this guest with se