446880-83-7

Basic information

• Product Name: 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine
• Synonyms: 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine
• CAS NO: 446880-83-7
• Molecular Formula: C₃₂H₂₃BrN₄
• Molecular Weight: 543.45582
• Mol File: 446880-83-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(446880-83-7)
• EPA Substance Registry System: 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine(446880-83-7)

Safety Data

• Hazardous Substances Data: 446880-83-7(Hazardous Substances Data)

Usage

General Description

The chemical compound 2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine, is a complex organic molecule consisting of a bromine atom, two pyridine rings, and a trityl group attached to a pyrazole ring. 2-broMo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine is commonly used in organic synthesis and pharmaceutical research due to its unique structure and properties. It may have potential applications in the development of new drugs or materials. Its synthesis and characterization are of interest to chemists and researchers in various fields.

Upstream product

• 446880-81-5 2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine 
• 76-83-5 trityl chloride 
• 446852-65-9 2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one 
• 4926-28-7 2-Bromo-4-picoline 
• 2524-52-9 ethyl-2-picolinate 

Downstream Products

• 452343-12-3 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzaldehyde 
• 452343-16-7 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester 
• 452343-14-5 (4-{4-[3-(2-pyridinyl)-1-trityl-1H-pyrazol-4-yl]-2-pyridinyl}phenyl)amine 
• 452343-10-1 2-(4-hydroxyphenyl)-4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridine 
• 886444-10-6 4-[4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid methyl ester 
• 452343-18-9 4-[4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridin-2-yl]benzoic acid 

Relevant articles and documents

ALK5 INHIBITOR CONJUGATES AND USES THEREOF

The present disclosure relates to targeted drug conjugates comprising ALK5 inhibitors and targeting moieties that direct the ALK5 inhibitors to cells involved in fibrosis and cancer, for example myofibroblasts, activated fibroblasts and transitioning fibr

ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES

The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling

Novel inhibitors of TGF-β1 and activin A signalling based on a 2-aryl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine pharmacophore have been synthesised. Compounds containing phenyl or aromatic nitrogen heterocycle substituents inhibited both types of signalling with HEK-293T cells in culture, with a selectivity preference for TGF-β1. Synthetic compounds containing pyridin-3-yl, pyrazol-4-yl, pyrazol-1-yl or 1H-imidazoyl-1-yl substituents exhibited structural and functional attributes suitable for further investigation related to the development of more potent TGF-β inhibitors.