447-41-6 Usage
Description
Nylidrin, also known as Buphenin, is a pharmaceutical compound with significant applications in the medical field. It possesses the ability to inhibit certain biological processes, making it a valuable asset for various therapeutic purposes.
Uses
Used in Pharmaceutical Industry:
Nylidrin is used as an antiallergic agent for its effectiveness in inhibiting the IgE-mediated release of histamine from human basophils. This property makes it a potential candidate for treating allergic reactions and conditions.
Used in Hepatology:
Nylidrin is used as an inhibitor of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP). This application is significant in the field of hepatology, as it can help regulate bile acid transport and potentially contribute to the treatment of liver-related disorders.
Originator
Arlidin,U.S.V. ,US,1955
Manufacturing Process
8 grams of the hydrobromide of 1-(p-benzoxyphenyl)-2-(α-methyl-γ-phenylpropylamino)-propanone-(1) were obtained by heating equivalent quantities of p-benzoxy-α-bromopropiophenone and 1-phenyl-3-amino-butane for an hour on the water bath in the absence of solvents. The product was purified by twice boiling with five times the quantity of acetic acid and filtration at 80°C, then shaken in contact with hydrogen with 0.8 gram of Raney nickel in 70 cc of pure methanol containing 0.96 gram (corresponding to 1 mol) of KOH. After 4 hours 2 mols of hydrogen had been taken up and the solution was filtered from the catalyst, evaporated in vacuo, and the residue triturated first with water to remove potassium bromide and then with methanol to remove potassium bromide. 3.7 grams (72% of the theoretical yield) of the compound specified, melting at 110° to 112°C, were obtained, as described in US Patent 2,661,373.
Therapeutic Function
Vasodilator
Check Digit Verification of cas no
The CAS Registry Mumber 447-41-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 447-41:
(5*4)+(4*4)+(3*7)+(2*4)+(1*1)=66
66 % 10 = 6
So 447-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H25NO2/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17/h3-7,10-15,19-22H,8-9H2,1-2H3
447-41-6Relevant articles and documents
Pharmaceutical formula
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, (2008/06/13)
The present invention concerns a pharmacological vehicle or carrier system, which makes possible administration of the active ingredient with a high absorption thereof in the blood circulation of the patient treated therewith, in particular also in the case of oral administration. The pharmacological vehicle system according to the invention comprises ultrafine particles of a reaction product of a reactive derivative of an at least dibasic inorganic acid or an alkane-carboxylic acid having 2 or 3 carboxyl groups and optionally one or two hydroxy groups, wherein one bond of the dibasic inorganic acid or one carboxy group of the alkane-carboxylic acid is bonded to a pharmacological active ingredient containing a hydroxy group, SH group and/or a primary or secondary amino group having a ractive hydrogen atom on this group, and the other bond is bonded to the free hydroxy group of a glycerolipid having at least one free hydroxy group on the glycerol. The invention further concerns these reaction products and a process for the preparation of ultrafine particles of these reaction products.
