447465-00-1

Basic information

• Product Name: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester
• Synonyms: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester
• CAS NO: 447465-00-1
• Molecular Weight: 394.491
• Mol File: 447465-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester(447465-00-1)
• EPA Substance Registry System: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester(447465-00-1)

Safety Data

• Hazardous Substances Data: 447465-00-1(Hazardous Substances Data)

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 26885-97-2 1-bromo-4-(p-tolylsulfonylmethyl)benzene 
• 541-41-3 chloroformic acid ethyl ester 
• 98-80-6 phenylboronic acid 

Downstream Products

• 447465-11-4 ethyl 2-(p-toluenesulfonyl)-2-(4-biphenylyl)-4-hexenoate 
• 959-10-4 2-([1,1'-biphenyl]-4-yl)butanoic acid 
• 6341-72-6 2-(4-biphenylyl)propanoic acid 
• 447465-05-6 ethyl 2-(p-toluenesulfonyl)-2-(4-biphenylyl)propanoate 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 447465-08-9 ethyl 2-(p-toluenesulfonyl)-2-(4-biphenylyl)butanoate 

Relevant articles and documents

Synthetic applications of o- and p-halobenzyl sulfones as zwitterionic synthons: Preparation of Ortho-substituted cinnamates and biarylacetic acids

The synthetic applications of o-halobenzyl and p-halobenzyl sulfones as precursors of 1,3- and 1,5-zwitterionic synthons, respectively, are described. Their α-sulfonyl carbanions, generated by means of the phosphazene base P2-Et or BuLi or K2CO3 under PTC conditions, reacted with different electrophiles such as alkyl halides, aldehydes, and electrophilic olefins. Palladium-catalyzed cross-coupling processes such as Heck, Suzuki, and Sonogashira reactions can be efficiently performed at the halogen atom. These two sequential functionalization processes are applied to the synthesis of ortho-substituted cinnamates and pharmaceuticals belonging to the family of p-biarylacetic acids such as 4-biphenylacetic acid, namoxyrate, xenyhexenic acid, and biphenylpropionic acid.