4475-59-6

Basic information

• Product Name: Benzene, 1-(4-fluorophenoxy)-2-nitro-
• Synonyms: 4-Fluor-1-(2-nitro-phenoxy)-benzol
• CAS NO: 4475-59-6
• Molecular Formula: C12H8FNO3
• Molecular Weight: 233.199
• Mol File: 4475-59-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 30-34 °C
• Boiling Point: 313.1±27.0 °C(Predicted)
• Density: 1.324±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-(4-fluorophenoxy)-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(4-fluorophenoxy)-2-nitro-(4475-59-6)
• EPA Substance Registry System: Benzene, 1-(4-fluorophenoxy)-2-nitro-(4475-59-6)

Safety Data

• Hazardous Substances Data: 4475-59-6(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 23530-43-0 2-(N,N-dimethylaminosulfonyl)nitrobenzene 
• 372-20-3 3-fluorophenol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 640766-67-2 2-(3-fluorophenoxy)aniline 
• 203303-06-4 1-(4-fluorophenoxy)-2-iodobenzene 
• 1316273-86-5 N-[2-(4-fluorophenoxy)phenyl]acetamide 
• 3169-71-9 1-(4-fluorophenoxy)-2-aminobenzene 

Relevant articles and documents

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design of new ligands. Structural comparison of our recently reported high resolution X-Ray structure of the cyclohexanedione derivative TUB075 bound to tubulin and the tubulin-DAMA-colchicine complex has revealed a conformational change in the αT5 loop. By a grid-based computational analysis of the tubulin-DAMA-colchicine binding site, we have identified a new favourable binding area in the colchicine-site that was unexplored by our lead TUB075. Thus, based on a structure-guided design, new cyclohexanedione derivatives have been synthesized and tested for tubulin binding and in cellular assays. As a result, we have identified diphenyl ether derivatives with IC50 values around 10–40 nM against three different tumor cell lines and affinity constants for tubulin similar to that of colchicine around 107 M?1. As expected, they halted the cell cycle progression at G2/M phase at concentrations as low as 0.08 μM.

Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches

A highly efficient palladium-catalyzed fourfold tandem-domino reaction consisting of two carbopalladation and two C-H-activation steps was developed for the synthesis of two types of tetrasubstituted alkenes 3 and 6 with intrinsic helical chirality starting from substrates 1 and 4, respectively. A sixfold tandem-domino reaction was also developed by including a Sonogashira reaction. 20 compounds with different substitution patterns were prepared with yields of up to 97%. Structure elucidation by X-ray crystallography confirmed helical chirality of the two alkene moieties. Photophysical investigations of some of the compounds showed pronounced switching properties through light-controlled changes of their stereochemical configuration.

Synthesis and enantioselective hydrogenation of seven-membered cyclic imines: Substituted dibenzo[b,f][1,4]oxazepines

Highly enantioselective hydrogenation of seven-membered cyclic imines, substituted dibenzo[b,f][1,4]oxazepines, was achieved, with up to 94% ee, by using the [Ir(COD)Cl]2/(S)-Xyl-C3*-TunePhos complex as the catalyst in the presence of morpholine-HCl.