4475-95-0 Usage
Description
2-amino-2-methylbutyronitrile is a yellow liquid with an ammonia-like odor. It has a flash point of 35°F and is approximately as dense as water. However, it is insoluble in water. 2-amino-2-methylbutyronitrile is toxic by ingestion, absorption, and inhalation, and it may also irritate the eyes. When burned, it produces toxic fumes. It is primarily used as a chemical intermediate for the synthesis of other chemicals.
Uses
Used in Chemical Synthesis:
2-amino-2-methylbutyronitrile is used as a chemical intermediate for the production of various chemicals. Its unique structure and reactivity make it a valuable building block in the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-amino-2-methylbutyronitrile is used as a key intermediate in the synthesis of certain drugs. Its ability to react with other molecules and form new chemical entities makes it an important component in the development of novel therapeutic agents.
Used in Agrochemical Industry:
2-amino-2-methylbutyronitrile is also utilized in the agrochemical industry for the production of various pesticides and other agricultural chemicals. Its role as a chemical intermediate allows for the creation of compounds that can help protect crops from pests and diseases, ultimately contributing to increased agricultural productivity.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-amino-2-methylbutyronitrile is employed in the development of unique and highly specialized chemical products. These may include compounds used in the manufacturing of dyes, coatings, adhesives, and other industrial applications where specific properties are required.
Overall, 2-amino-2-methylbutyronitrile is a versatile chemical intermediate with a wide range of applications across different industries, primarily due to its unique chemical properties and reactivity.
Synthesis Reference(s)
Journal of the American Chemical Society, 82, p. 696, 1960 DOI: 10.1021/ja01488a049
Air & Water Reactions
Highly flammable. Insoluble in water.
Health Hazard
TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Check Digit Verification of cas no
The CAS Registry Mumber 4475-95-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,7 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4475-95:
(6*4)+(5*4)+(4*7)+(3*5)+(2*9)+(1*5)=110
110 % 10 = 0
So 4475-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N2/c1-3-5(2,7)4-6/h3,7H2,1-2H3
4475-95-0Relevant articles and documents
Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia
Li, Qing-Hua,Li, Zhao-Feng,Tao, Jing,Li, Wan-Fang,Ren, Li-Qing,Li, Qian,Peng, Yun-Gui,Liu, Tang-Lin
supporting information, p. 8429 - 8433 (2019/10/14)
α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.
Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones
Zali-Boeini, Hassan,Mobin, Mehdi,Hajibabaei, Khadijeh,Ghani, Maryam
experimental part, p. 5808 - 5812 (2012/07/31)
Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.
An automatic solid-phase synthesis of peptaibols
Hjorringgaard, Claudia U.,Pedersen, Jan M.,Vosegaard, Thomas,Nielsen, Niels Chr,Skrydstrup, Troels
supporting information; experimental part, p. 1329 - 1332 (2009/08/08)
An automated approach to peptaibols using microwave-assisted solid-phase peptide synthesis is demonstrated with a combination of HBTU and acid fluoride mediated couplings for normal and α,α-dialkylated amino acids, respectively. The method is utilized for