448184-48-3 Usage
Description
2-2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide is a complex organic compound characterized by its unique molecular structure. It is an N-oxide derivative of an imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one, featuring a sulfonylphenyl group and a piperazinyl moiety, which may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide is used as an impurity compound for the development of Vardenafil Hydrochloride, a medication used in the treatment of erectile dysfunction. Its presence in the pharmaceutical compound may affect the efficacy and safety profile of the drug, making it an important consideration in the drug development process.
Used in Enzyme Inhibition:
2-2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide is also used as an inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme. By inhibiting PDE-5, it can potentially enhance the effects of nitric oxide, which is involved in the regulation of blood flow, and thus may contribute to the treatment of conditions related to blood flow regulation, such as erectile dysfunction.
Check Digit Verification of cas no
The CAS Registry Mumber 448184-48-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,1,8 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 448184-48:
(8*4)+(7*4)+(6*8)+(5*1)+(4*8)+(3*4)+(2*4)+(1*8)=173
173 % 10 = 3
So 448184-48-3 is a valid CAS Registry Number.
448184-48-3Relevant articles and documents
Synthesis and spectral characterization of related substances of vardenafil, an erectile dysfunction drug
Reddy, Vajrala Venkata,Naga Brahmeswara Rao, Mandava Venkata,Reddy, Ghanta Mahesh,Mukkanti, Khagga,Reddy, Ganta Madhusudhan
experimental part, p. 3513 - 3523 (2012/10/18)
Vardenafil hydrochloride trihydrate (Levitra) is used to treat erectile dysfunction (ED) and is an inhibitor of phosphodiesterase type 5 (PDE-5) enzyme. It maintains higher levels of cyclic guanosine monophosphate (cGMP), relaxes smooth muscles, promotes penile blood flow, and enhances erectile function. During the bulk drug synthesis of vardenafil hydrochloride trihydrate, six related substances (impurities), vardenafil dimer, vardenafil N-oxide, vardenafil glycene, vardenafil oxopiperazine, vardenafil oxoacetic acid, and phenyl vardenafil were identified, and these are reported herein for the first time. The present work describes the synthesis and characterization of these impurities.
