Cas 448235-62-9,Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1<sup>(21)</sup>,4,6,10,18-pentaen-9-yl ester

448235-62-9

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Product Name: Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1⁽²¹⁾,4,6,10,18-pentaen-9-yl ester
Synonyms:
CAS NO:448235-62-9
Molecular Formula:
Molecular Weight: 781.904
EINECS: N/A
Product Categories: N/A
Mol File: 448235-62-9.mol
Article Data: 1

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1⁽²¹⁾,4,6,10,18-pentaen-9-yl ester(CAS DataBase Reference)
NIST Chemistry Reference: Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1⁽²¹⁾,4,6,10,18-pentaen-9-yl ester(448235-62-9)
EPA Substance Registry System: Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1⁽²¹⁾,4,6,10,18-pentaen-9-yl ester(448235-62-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 448235-62-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 448235-62-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,2,3 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 448235-62:
(8*4)+(7*4)+(6*8)+(5*2)+(4*3)+(3*5)+(2*6)+(1*2)=159
159 % 10 = 9
So 448235-62-9 is a valid CAS Registry Number.

448235-62-9Upstream product

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448235-62-9Relevant articles and documents

Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin(TM) immunoconjugate

Mandler, Raya,Dadachova, Ekaterina,Brechbiel, James K.,Waldmann, Thomas A.,Brechbiel, Martin W.

, p. 1025 - 1028 (2000)

Geldanamycin was modified with 1,4-diaminobutane to introduce a primary amine that was subsequently employed to provide a maleimide for protein linkage. Monoclonal antibody Herceptin(TM) was then derivatized to generate thiol groups that reacted with the maleimide derivative to produce the immunoconjugate. The product showed antiproliferative activity greater than native Herceptin(TM). (C) 2000 Elsevier Science Ltd. All rights reserved.

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