448956-36-3Relevant articles and documents
Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
Tu, Noah,Link,Sorensen, Bryan K.,Emery, Maurice,Grynfarb, Marlena,Goos-Nilsson, Annika,Nguyen, Bach
, p. 4179 - 4183 (2007/10/03)
Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.