448963-26-6

Basic information

• Product Name: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-ureido-pentanoic acid
• CAS NO: 448963-26-6
• Molecular Weight: 422.481
• Mol File: 448963-26-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-ureido-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-ureido-pentanoic acid(448963-26-6)
• EPA Substance Registry System: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-ureido-pentanoic acid(448963-26-6)

Safety Data

• Hazardous Substances Data: 448963-26-6(Hazardous Substances Data)

Upstream product

• 3160-59-6 N-Cbz-L-Isoleucine 
• 372-75-8 Citrulline 
• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 

Downstream Products

• 448963-38-0 Carbonic acid 4-[(S)-2-((2S,3S)-2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-ureido-pentanoylamino]-benzyl ester 4-nitro-phenyl ester 
• 448963-31-3 {(1S,2S)-1-[(S)-1-(4-Hydroxymethyl-phenylcarbamoyl)-4-ureido-butylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester 

Relevant articles and documents

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.