4501-52-4

Basic information

• Product Name: 2-cyclohexyl-1,4-dimethylbenzene
• Synonyms: 1,4-Dimethyl-2-cyclohexylbenzene; 2-Cyclohexyl-1,4-dimethylbenzene; benzene, 2-cyclohexyl-1,4-dimethyl-
• CAS NO: 4501-52-4
• Molecular Formula: C₁₄H₂₀
• Molecular Weight: 188.3086
• Mol File: 4501-52-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 283.1°C at 760 mmHg
• Flash Point: 126.1°C
• Density: 0.926g/cm³
• Vapor Pressure: 0.00552mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 2-cyclohexyl-1,4-dimethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexyl-1,4-dimethylbenzene(4501-52-4)
• EPA Substance Registry System: 2-cyclohexyl-1,4-dimethylbenzene(4501-52-4)

Safety Data

• Hazardous Substances Data: 4501-52-4(Hazardous Substances Data)

Upstream product

• 106-42-3 para-xylene 
• 953-91-3 cyclohexyl tosylate 
• 110-83-8 cyclohexene 
• 100793-20-2 2-Bromomethyl-benzoic acid cyclohexyl ester 
• 538-75-0 dicyclohexyl-carbodiimide 
• 71-43-2 benzene 
• 4351-54-6 cyclohexyl formate 
• 108-93-0 cyclohexanol 
• 16156-56-2 cyclohexyl mesylate 
• 7446-70-0 aluminium trichloride 
• 542-18-7 cyclohexyl chloride 
• 98-95-3 nitrobenzene 
• 60260-74-4 (methylsulfonyl)cyclohexane 
• 108-85-0 1-bromocyclohexane 

Downstream Products

• 2523-39-9 3-methylfluorene 
• 92254-03-0 5-methyl-[1,1'-biphenyl]-2-carboxylic acid 
• 95-87-4 2,5-Dimethylphenol 
• 108-94-1 cyclohexanone 
• 1314905-81-1 (E)-4-(2,5-dimethyl-4-cyclohexylphenyl)-4-oxo-2-butenoic acid 

Relevant articles and documents

Friedel-Crafts Cyclohexylation of Arenes with 1,3-Dicyclohexylcarbodiimide (DCC)

The reaction of arenes with 1,3-dicyclohexylcarbodiimide in the presence of concentrated sulfuric acid or anhydrous aluminum chloride gave the corresponding cyclohexylated arenes in good yields.

Iron-catalyzed arene alkylation reactions with unactivated secondary alcohols

A simple, iron-based catalytic system allows for the inter- and intramolecular arylation of unactivated secondary alcohols. This transformation expands the substrate scope beyond the previously required activated alcohols and proceeds under mild reaction conditions, tolerating air and moisture. Furthermore, the use of an enantioenriched secondary alcohol provides an enantioenriched product for the intramolecular reaction, thereby offering a convenient approach to nonracemic products.

Nitrosonium salts, NO+X- (X = B(3,5-diCF 3Ph)4- or PW12O40 3-), as electrophilic catalysts for alkene activation in arene alkylation and dimerization reactions

It has been found that in apolar reaction media the nitrosonium cation (NO+) activated alkenes under mild conditions toward electrophilic substitution of arene substrates to yield the alkylated arene with Markovnikov orientation. In the absence of arenes the alkenes react with themselves to yield a mixture of dimeric alkenes. The nitrosonium cation can be dissolved in the reaction medium by using the tetrakis-(bis-(3,5-trifluromethyl)phenyl) borate anion, where upon the reactions occur effectively at 30 °C. Alternatively an insoluble, heterogeneous catalyst was prepared so as to yield a NO+ cation with a polyoxometalate (PW12O403-) anion. This catalyst was generally more effective and selective toward a broader range of substrates at 70 °C. Copyright