450364-01-9

Basic information

• Product Name: C₂₀H₂₁NO₂
• Synonyms: C₂₀H₂₁NO₂
• CAS NO: 450364-01-9
• Molecular Weight: 307.392
• Mol File: 450364-01-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₁NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₁NO₂(450364-01-9)
• EPA Substance Registry System: C₂₀H₂₁NO₂(450364-01-9)

Safety Data

• Hazardous Substances Data: 450364-01-9(Hazardous Substances Data)

Upstream product

• 135-19-3 β-naphthol 
• 5234-06-0 [(2-naphthalenyloxy)methyl]oxirane 
• 100-46-9 benzylamine 

Relevant articles and documents

Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents

Herein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems. All β-amino alcohol derivatives of totarol exhibited higher antiplasmodial activity than totarol [IC50: 11.69 μM (K1, chloroquine and multi-drug resistant strain), and 11.78 μM (D10, chloroquine sensitive strain)] - 12e was the most active [IC50: 0.63 μM (K1), and 0.61 μM (D10)]. The phenyl and naphthyl β-amino alcohol derivatives were much less active than their corresponding totarol equivalents. The majority of the β-amino alcohol derivatives of totarol were more active against K1 than the D10 strains of Plasmodium falciparum, a trend similar to the inverse relationship observed with the established aryl-amino alcohol antimalarial mefloquine. Selected compounds were shown to affect erythrocyte morphology, inhibit erythrocyte invasion and trigger CQ accumulation.