450370-35-1Relevant articles and documents
Umpolung Amide Synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen AS a terminal oxidant
Schwieter, Kenneth E.,Shen, Bo,Shackleford, Jessica P.,Leighty, Matthew W.,Johnston, Jeffrey N.
, p. 4714 - 4717 (2014)
Umpolung Amide Synthesis (UmAS) provides direct access to amides from an α-bromo nitroalkane and an amine. Based on its mechanistic bifurcation after convergent C-N bond formation, depending on the absence or presence of oxygen, UmAS using substoichiometric N-iodosuccinimide (NIS) under aerobic conditions has been developed. In combination with the enantioselective preparation of α-bromo nitroalkane donors, this protocol realizes the goal of enantioselective α-amino amide and peptide synthesis based solely on catalytic methods.
ASYMMETRIC SYNTHESIS OF 1-METHYL-2-(2-HYDROXYETHYL)PYRROLIDINE
Nikiforov, Theo,Stanchev, Stephan,Milenkov, Branimir,Dimitrov, Vladimir
, p. 1825 - 1829 (2007/10/02)
An asymmetric synthesis of 1-methyl-2-(2-hydroxyethyl)pyrrolidine based on optically active 1-phenylethylamine is described.