4507-41-9

Basic information

• Product Name: α-Amino-α-methyl benzene acetic methyl ester
• Synonyms: α-Amino-α-methyl benzene acetic methyl ester;methyl 2-amino-2-phenylpropionate
• CAS NO: 4507-41-9
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 4507-41-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 254.8±20.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• PKA: 6.68±0.10(Predicted)
• CAS DataBase Reference: α-Amino-α-methyl benzene acetic methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-Amino-α-methyl benzene acetic methyl ester(4507-41-9)
• EPA Substance Registry System: α-Amino-α-methyl benzene acetic methyl ester(4507-41-9)

Safety Data

• Hazardous Substances Data: 4507-41-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 48, p. 7713, 1992 DOI: 10.1016/S0040-4020(01)90382-5

Upstream product

• 67-56-1 methanol 
• 565-07-1 2-amino-2-phenylpropanoic acid 
• 148600-14-0 methyl 2-azido-2-phenylpropanoate 
• 91292-73-8 (+/-)-(4-chlorobenzylidene)alanine methyl ester 
• 115134-32-2 methyl 2-((diphenylmethylene)amino)propanoate 
• 135998-79-7 methyl 2-(o-chlorobenzylideneamino)propionate 
• 492-37-5 hydratropic acid 
• 87786-35-4 2-bromo-2-phenyl-propionic acid 
• 84892-13-7 methyl 2-bromo-2-phenylpropanoate 
• 32346-08-0 (1-methoxy-2-phenylprop-1-enyloxy)trimethylsilane 
• 1462367-32-3 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione 
• 6844-34-4 3,5-dimethyl-5-phenylimidazolidine-2,4-dione 
• 98-86-2 acetophenone 
• 613-91-2 acetophenone oxime 

Downstream Products

• 4507-51-1 Trifluoracetyl-DL-α-phenyl-alanyl-DL-α-phenyl-alanin-methylester 
• 124658-21-5 Methyl α-fluoro-α-methylbenzeneacetate 
• 148600-15-1 (+/-)-2-Fluoro-2-phenylpropionic acid 
• 1056442-66-0 2-amino-N-methyl-2-phenyl-propionamide 

Relevant articles and documents

Bifunctional iminophosphorane organocatalysts for enantioselective synthesis: Application to the ketimine nitro-Mannich reaction

The design, synthesis, and development of a new class of modular, strongly basic, and tunable bifunctional Bronsted base/H-bond-donor organocatalysts are reported. These catalysts incorporate a triaryliminophosphorane as the Bronsted basic moiety and are readily synthesized via a last step Staudinger reaction of a chiral organoazide and a triarylphosphine. Their application to the first general enantioselective organocatalytic nitro-Mannich reaction of nitromethane to unactivated ketone-derived imines allows the enantioselective construction of β-nitroamines possessing a fully substituted carbon atom. The reaction is amenable to multigram scale-up, and the products are useful for the synthesis of enantiopure 1,2-diamine and α-amino acid derivatives.

Acide 2-fluoro-2-phenyl propanoique: preparation et utilisation comme agent chiral de derivation

The enantiomers of 2-fluoro-2-phenyl propanoic acid have been separated and their absolute configurations determined: the specific rotation of the acid with an R configuration is 20D= -28.5 deg (c=1.5, ethanol).This acid has been

Reaction of Enol Ethers and Silyl Ketene Acetals with 3-Acetoxyamino-2-ethylquinazolin-4(3H)-one: Cleavage of N-N bonds in 3-Alkylaminoquinazolin-4(3H)-ones

Treatment of enol ethers and silyl ketene acetals with the N-acetoxyaminoquinazolone 1 gives α-aminoaldehyde, α-aminoketone or α-aminoacid derivatives in good yields: cleavage of the N-N bond in 3-alkylaminoquinazolinone derivatives can be accomplished by samarium diodide in tetrahydrofuran.