450836-82-5

Basic information

• Product Name: 6-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-3'-methoxy(1,1'-biphenyl)-3-carbonitrile
• CAS NO: 450836-82-5
• Molecular Weight: 434.497
• Mol File: 450836-82-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-3'-methoxy(1,1'-biphenyl)-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-3'-methoxy(1,1'-biphenyl)-3-carbonitrile(450836-82-5)
• EPA Substance Registry System: 6-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-3'-methoxy(1,1'-biphenyl)-3-carbonitrile(450836-82-5)

Safety Data

• Hazardous Substances Data: 450836-82-5(Hazardous Substances Data)

Upstream product

• 371765-91-2 4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 60710-80-7 5-cyano-2-methylaniline 
• 39478-78-9 5-bromo-2-methylaniline 
• 42872-79-7 3-iodo-4-methylbenzonitrile 
• 10365-98-7 3-methoxyphenylboronic acid 
• 450844-38-9 5-[(4-cyano-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole 

Relevant articles and documents

Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.