450839-69-7Relevant articles and documents
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)- 1H-imidazole as novel farnesyltransferase inhibitor
Lin, Nan-Horng,Wang, Le,Wang, Xilu,Wang, Gary T.,Cohen, Jerry,Gu, Wen-Zhen,Zhang, Haiying,Rosenberg, Saul H.,Sham, Hing L.
, p. 5057 - 5062 (2004)
Analogs of compound 1 were synthesized and tested in vitro for farnesyltransferase inhibition activity.
Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors
Wang, Le,Wang, Gary T.,Wang, Xilu,Tong, Yunsong,Sullivan, Gerry,Park, David,Leonard, Nicholas M.,Li, Qun,Cohen, Jerry,Gu, Wen-Zhen,Zhang, Haiying,Bauch, Joy L.,Jakob, Clarissa G.,Hutchins, Charles W.,Stoll, Vincent S.,Marsh, Kennan,Rosenberg, Saul H.,Sham, Hing L.,Lin, Nan-Horng
, p. 612 - 626 (2007/10/03)
A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-
Farnesyltransferase inhibitors
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, (2008/06/13)
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
