4509-91-5

Basic information

• Product Name: 1-Pentanone, 5-bromo-1-phenyl-
• CAS NO: 4509-91-5
• Molecular Formula: C11H13BrO
• Molecular Weight: 241.128
• Mol File: 4509-91-5.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1-Pentanone, 5-bromo-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanone, 5-bromo-1-phenyl-(4509-91-5)
• EPA Substance Registry System: 1-Pentanone, 5-bromo-1-phenyl-(4509-91-5)

Safety Data

• Hazardous Substances Data: 4509-91-5(Hazardous Substances Data)

Usage

Classification

Aryl ketone

Appearance

Colorless to pale yellow liquid

Odor

Fruity

Common Uses

Intermediate in pharmaceutical and agrochemical industries

Applications

Synthesis of pharmaceuticals, flavors and fragrances, production of organic compounds

Uses

Reagent in organic synthesis, building block for biologically active molecules

Notable Feature

Presence of bromine atom on the phenyl ring, making it an important chemical in organic synthesis.

Upstream product

• 13544-26-8 6-phenyl-3,4-dihydro-2H-pyran 
• 5414-21-1 5-bromopentan-1-nitrile 
• 10035-10-6 hydrogen bromide 
• 41034-84-8 2-phenyl-5,6-dihydro-4H-pyran-3-carboxylic acid 
• 4509-90-4 5-bromovaleroyl chloride 
• 71-43-2 benzene 
• 28557-00-8 phenylzinc chloride 
• 344294-88-8 5-bromo-2-cyano-valeric acid ethyl ester 
• 98-80-6 phenylboronic acid 
• 10487-96-4 1-phenylcyclopentanol 
• 2067-33-6 5-bromopentanoic acid 
• 100-58-3 phenylmagnesium bromide 
• 4144-62-1 5-benzoylvaleric acid 
• 20614-62-4 (1-hydroperoxycyclopentyl)benzene 

Downstream Products

• 101878-40-4 5-(4-nitro-phenoxy)-1-phenyl-pentan-1-one 
• 13544-26-8 6-phenyl-3,4-dihydro-2H-pyran 
• 144227-02-1 2-phenyl-2-(4-bromobutyl)-1,3-dithiolane 
• 10035-10-6 hydrogen bromide 
• 1076691-61-6 2-(5-oxo-5-phenylpentyloxy)isoindoline-1,3-dione 
• 1199941-54-2 8-bromo-4-phenyloct-1-en-4-ol 

Relevant articles and documents

Synthesis of chiral branched allylamines through dual photoredox/nickel catalysis

Allylamines are versatile building blocks in the synthesis of various naturally occurring products and pharmaceuticals. In contrast to terminal allylamines, the methods of synthesis of their branched congeners with internal, stereodefined double bonds are less explored. This work describes a new approach for the preparation of allylaminesviacross-coupling of alkyl bromides with simple 3-bromoallylamines by merging the photoredox approach and Ni catalysis. The reaction proceeds under mild conditions, under blue light irradiation, and in the presence of an organic dye, 4CzIPN, as a photocatalyst. The scope of suitable reaction partners is broad, including alkyl bromides bearing reactive functionalities (e.g., esters, nitriles, aldehydes, ketones, epoxides) andN-protected allylamines, as well asN-allylated secondary and tertiary amines and heterocycles. The employment of non-racemic starting materials allows for rapid and easy construction of complex multifunctional allylamine derivatives without the loss of enantiomeric purity.

In-situ-generation of alkylsilyl peroxides from alkyl hydroperoxides and their subsequent copper-catalyzed functionalization with organosilicon compounds

Alkylsilyl peroxides were generated in situ from the corresponding alkyl hydroperoxides using organosilicon compounds of the type Me3SiX (X = CN, N3, and halogens) and an amine base. Subsequent in situ copper-catalyzed homolytic cleavage of the alkylsilyl peroxides afforded alkyl radicals, which were then trapped with X (X = CN, N3, and halogens) to furnish products with new carbon-carbon, carbon-nitrogen, or carbon-halogen bonds in good to high yields.

Copper-catalyzed radical ring-opening halogenation with HX

An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields. This journal is