4512-62-3

Basic information

• Product Name: diethyl methyl(naphthalen-1-ylmethyl)propanedioate
• CAS NO: 4512-62-3
• Molecular Formula: C₁₉H₂₂O₄
• Molecular Weight: 314.3756
• Mol File: 4512-62-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 423.6°C at 760 mmHg
• Flash Point: 207.2°C
• Density: 1.127g/cm³
• Vapor Pressure: 2.21E-07mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: diethyl methyl(naphthalen-1-ylmethyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl methyl(naphthalen-1-ylmethyl)propanedioate(4512-62-3)
• EPA Substance Registry System: diethyl methyl(naphthalen-1-ylmethyl)propanedioate(4512-62-3)

Safety Data

• Hazardous Substances Data: 4512-62-3(Hazardous Substances Data)

Upstream product

• 18424-77-6 sodium diethyl methylmalonate 
• 86-52-2 1-Chloromethylnaphthalene 
• 3163-27-7 2-(bromomethyl)naphthalene 
• 609-08-5 Diethyl methylmalonate 
• 141-52-6 sodium ethanolate 
• 74-88-4 methyl iodide 
• 4780-79-4 1-naphthalene methanol 

Downstream Products

• 4512-61-2 Methyl-<1-naphthyl-methyl>-malonsaeure 

Relevant articles and documents

Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile. We have achieved the nickel-catalyzed benzylic substitution of benzyl esters with malonates as a soft carbon nucleophile. Primary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates as well as a wide variety of malonate derivatives were well tolerated in the nickel-catalyzed reaction, providing the corresponding alkylation products in 46-86% yields (34 examples). Additionally, we propose a possible reaction mechanism that would undergo via the ??1- A nd ??3-benzylnickel intermediates.

Palladium-catalyzed nucleophilic benzylic substitutions of benzylic esters

A palladium complex generated in situ from [Pd(η3-C3H5)(cod)]BF4 and DPPF is a good catalyst for benzylic alkylation of benzyl methyl carbonate with the carbanion of dimethyl malonates. The catalytic reaction is applicable to a wide range of the benzylations of benzylic esters with malonates. The catalytic activity was heavily affected by the bite angle of the bidentate phosphine ligand on palladium. DPEphos ligand is superior to DPPF in the case of palladium-catalyzed benzylic amination of benzylic esters. Copyright