4514-53-8

Basic information

• Product Name: 6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE
• Synonyms: 2,4-DIAMINO-6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE;6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE;TIMTEC-BB SBB003345;6-(4-Chlorophenyl)-2,4-diamino-1,3,5-triazine;2,4-DIAMINO-6-(4-CHLOROPHENYL)-1,3,5-TR&;6-(4-Chlorophenyl)-2,4-diamino-1,3,5-triazine 97%;1,3,5-Triazine-2,4-diaMine, 6-(4-chlorophenyl)-;6-(4-Chlorophenyl)-2,4-diamino-1,3,5-triazine97%
• CAS NO: 4514-53-8
• Molecular Formula: C₉H₈ClN₅
• Molecular Weight: 221.65
• Product Categories: Halogenated Heterocycles;Heterocyclic Building Blocks;Triazines;TriazinesBuilding Blocks
• Mol File: 4514-53-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 248-252 °C(lit.)
• Boiling Point: 513.5 °C at 760 mmHg
• Flash Point: 264.4 °C
• Appearance: /
• Density: 1.468 g/cm³
• Vapor Pressure: 1.17E-10mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE(4514-53-8)
• EPA Substance Registry System: 6-(4-CHLOROPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE(4514-53-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 4514-53-8(Hazardous Substances Data)

Usage

General Description

6-(4-Chlorophenyl)-1,3,5-triazine-2,4-diamine, also known as rufinamide, is a chemical compound that is used as an anticonvulsant medication. It acts by regulating the activity of sodium channels, which helps to prevent the excessive and abnormal electrical activity in the brain that leads to seizures. Rufinamide is primarily used in the treatment of Lennox-Gastaut syndrome, a severe form of childhood epilepsy that is often resistant to other anti-seizure medications. It is typically administered orally in the form of tablets or a suspension, and its effectiveness and safety have been established through clinical trials and long-term use in patients with epilepsy.(CancellationToken: The information provided here is for educational purposes only and should not be used to guide medical treatment. Please consult a healthcare professional for personalized advice.)

InChI:InChI=1/C9H8ClN5/c10-6-3-1-5(2-4-6)7-13-8(11)15-9(12)14-7/h1-4H,(H4,11,12,13,14,15)

Upstream product

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Green synthesis and self-association of 2,4-diamino-1,3,5-triazine derivatives

2,4-Diamino-1,3,5-triazines have been prepared by reaction of dicyandiamide with nitriles under microwave irradiation, a method that can be considered as a green procedure due to the reduction in the use of solvents during synthesis and purification, the short reaction time and the simplicity of the procedure. The structures have been confirmed in solution by NMR spectroscopy. Variable temperature experiments have been used to calculate the free energy of activation for rotation about the amino-triazine bond. The crystal structures of three 2,4-diamino-6-R-1,3,5-triazine derivatives (3a: R = phenyl, 3i: R = 1-piperidino and 3g: R = 1-phenylpyrazol-3-yl) have been determined by X-ray analysis. The N-H...N interactions change from structure to structure, resulting in a variation from pseudo-honeycomb networks to corrugated rosette layers.

ANTICANCER COMPOSITION AND COMPOUND

An anticancer composition containing a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof. In formula (I), R10 and R20 may be the same or different from each other and each represents hydrogen, halogen, amino, aralkylamino, nitro, lower alkyl, lower alkoxy, lower alkoxyalkoxy, lower aralkyloxy or acyl; R30 and R40 may be the same or different from each other and each represents hydrogen, nicotinoyl, benzoyl or lower alkoxy; and n represents 0 or 1.