451459-95-3

Basic information

• Product Name: 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
• Synonyms: 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
• CAS NO: 451459-95-3
• Molecular Weight: 270.217
• Mol File: 451459-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid(451459-95-3)
• EPA Substance Registry System: 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid(451459-95-3)

Safety Data

• Hazardous Substances Data: 451459-95-3(Hazardous Substances Data)

Upstream product

• 108-55-4 glutaric anhydride, 
• 369-36-8 6-fluoro-3-nitroaniline 

Downstream Products

• 3543-72-4 4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester 
• 3543-73-5 ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate 
• 3543-74-6 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester 
• 3543-75-7 bendamustine hydrochloride 
• 31349-48-1 4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid 

Relevant articles and documents

Process for preparation of Bendamustine

The present invention relates to a method for preparation of alkyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoate (7) from 2-fluoro-5-nitroaniline, comprising the steps of: a) conversion of 2-fluoro-5-nitroaniline to 5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid (1) using glutaric anhydride, conversion of compound (1) to methylammonium 5-[2-(methylamino)-5-nitroanilino]-5-oxopentanoate (2) using methylamine; conversion of compound (2) to 5-[2-(methylamino)-5-nitroanilino]-5-oxopentanoic acid (3) and condensation of compound (3) to 4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid (4), b) esterification of the product (4) of step a) to alkyl 4-(1-methyl-5-nitro1H-benzimidazol-2-yl)butanoate (5), c) reduction of the product of step b) to alkyl 4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate (6), and d) conversion of the product of step c) to alkyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoate (7).