451494-86-3

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
• CAS NO: 451494-86-3
• Molecular Formula: C16H10ClF4N3O4S
• Molecular Weight: 451.786
• Mol File: 451494-86-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester(451494-86-3)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester(451494-86-3)

Safety Data

• Hazardous Substances Data: 451494-86-3(Hazardous Substances Data)

Upstream product

• 184475-71-6 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline 

Downstream Products

• 451493-42-8 C₂₅H₂₇ClFN₅O 
• 722458-71-1 4-[(3-chloro-4-fluoro-phenyl)amino]-7-methoxy-6-(dimethylphosphinoyl)-quinazoline 
• 1214731-91-5 C₂₀H₁₉ClFN₃OSi 

Relevant articles and documents

QUINAZOLINE DERIVATIVES

A quinazoline derivative of the formula (I) wherein: R1, R2, R3, R3a, R4, R5, R5a R6, R7, a, m and p are as defined in the description. Also claimed are pharmaceutical compositions containing the quinazoline derivative, the use of the quinazoline derivatives as medicaments and processes for the preparation of the quinazoline derivative. The quinazoline derivatives of formula (I), are useful in the treatment of hyperproliferative disorders such as a cancer.

Quinazoline derivatives

A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.