452056-87-0

Basic information

• Product Name: Acetamide, N-[4-[4-(4-fluorophenyl)-1-(3-hydroxypropyl)-3-oxido-1H-imidazol-5-yl]-2 -pyridinyl]-
• CAS NO: 452056-87-0
• Molecular Formula: C19H19FN4O3
• Molecular Weight: 370.383
• Mol File: 452056-87-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-[4-(4-fluorophenyl)-1-(3-hydroxypropyl)-3-oxido-1H-imidazol-5-yl]-2 -pyridinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-[4-(4-fluorophenyl)-1-(3-hydroxypropyl)-3-oxido-1H-imidazol-5-yl]-2 -pyridinyl]-(452056-87-0)
• EPA Substance Registry System: Acetamide, N-[4-[4-(4-fluorophenyl)-1-(3-hydroxypropyl)-3-oxido-1H-imidazol-5-yl]-2 -pyridinyl]-(452056-87-0)

Safety Data

• Hazardous Substances Data: 452056-87-0(Hazardous Substances Data)

Upstream product

• 61112-42-3 3-[3,5-bis(3-hydroxypropyl)[1,3,5]triazinan-1-yl]propan-1-ol 
• 452056-82-5 N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide 
• 452056-79-0 N-{4-[2-cyano-2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 452056-81-4 N-{4-[2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 452056-80-3 1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 459-22-3 4-fluorophenylacetonitrile 

Downstream Products

• 452056-92-7 N-{4-[5-(4-fluorophenyl)-3-(3-hydroxypropyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl]pyridin-2-yl}acetamide 

Relevant articles and documents

Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors

The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole seri

Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position

We prepared novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity by using our previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently