452071-65-7

Basic information

• Product Name: p-methoxybenzyl 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranoside
• Synonyms: p-methoxybenzyl 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranoside
• CAS NO: 452071-65-7
• Molecular Weight: 549.618
• Mol File: 452071-65-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-methoxybenzyl 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: p-methoxybenzyl 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranoside(452071-65-7)
• EPA Substance Registry System: p-methoxybenzyl 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranoside(452071-65-7)

Safety Data

• Hazardous Substances Data: 452071-65-7(Hazardous Substances Data)

Upstream product

• 452071-48-6 phenyl 3-N,4-O-di-allyloxycarbonyl-3-amino-1-thio-2,3,6-trideoxy-α-L-arabino-hexopyranoside 
• 452071-47-5 methyl 3-N,4-O-di-allyloxycarbonyl-2,3,6-trideoxy-3-amino-α-L-arabino-hexopyranoside 
• 452071-61-3 p-methoxybenzyl 4-O-benzoyl-2,3,6-trideoxy-α-L-lyxo-hexopyranoside 
• 452071-58-8 p-methoxybenzyl 4-O-acetyl-2,3,6-trideoxy-α-L-arabino-hexopyranoside 
• 452071-62-4 p-methoxybenzyl 2,3,6-trideoxy-α-L-lyxo-hexopyranoside 
• 452071-59-9 p-methoxybenzyl 2,3,6-trideoxy-α-L-arabino-hexopyranoside 
• 105-13-5 4-Methoxybenzyl alcohol 
• 54623-23-3 methyl-3-amino-2,3,6-tridesoxy-α-L-arabino-hexopyranoside 

Downstream Products

• 452071-66-8 4-O-(3-N,4-O-di-allyloxycarbonyl-3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-2,3,6-trideoxy-1-O-p-nitrobenzoyl-α-L-lyxo-hexopyranoside 

Relevant articles and documents

Novel anthracycline oligosaccharides: Influence of chemical modifications of the carbohydrate moiety on biological activity

Several observations highlight the importance of the carbohydrate moiety for the biological activity of antitumoural anthracyclines. Here is reported the synthesis, cytotoxicity and topoisomerase II-mediated DNA cleavage intensity of the new oligosaccharide anthracyclines 1-4 modified in the sugar residue. Evaluation of cytotoxic potency on different cell lines, resulted in quite similar values among the different analogues. On the other hand, topoisomerase II-mediated DNA breaks level was different for the various compounds, and was not related to cytotoxicity, thus supporting previous observations reported for some monosaccharide anthracyclines modified in the carbohydrate portion.