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452339-74-1

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452339-74-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 452339-74-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,3,3 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 452339-74:
(8*4)+(7*5)+(6*2)+(5*3)+(4*3)+(3*9)+(2*7)+(1*4)=151
151 % 10 = 1
So 452339-74-1 is a valid CAS Registry Number.

452339-74-1Downstream Products

452339-74-1Relevant articles and documents

The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group

Procopiou, Panayiotis A.,Barrett, Victoria J.,Ford, Alison J.,Looker, Brian E.,Lunniss, Gillian E.,Needham, Deborah,Smith, Claire E.,Somers, Graham

scheme or table, p. 6026 - 6032 (2011/11/07)

A series of novel, potent and selective human β2 adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and also in vivo similar to that of salmeterol. It had lower oral absorption and bioavailability than salmeterol in both rat and dog. It had a turnover ratio similar to salmeterol, with no evidence for formation of any aniline metabolites in human liver microsomes and hepatocytes. However no crystalline salts suitable for inhaled delivery were identified.

PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

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Page 41-42, (2010/02/06)

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

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