4525-62-6

Basic information

• Product Name: p-bromophenyl formate
• Synonyms: p-bromophenyl formate
• CAS NO: 4525-62-6
• Molecular Weight: 201.019
• Mol File: 4525-62-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: p-bromophenyl formate(CAS DataBase Reference)
• NIST Chemistry Reference: p-bromophenyl formate(4525-62-6)
• EPA Substance Registry System: p-bromophenyl formate(4525-62-6)

Safety Data

• Hazardous Substances Data: 4525-62-6(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 108-86-1 bromobenzene 
• 556-63-8 lithium formate 
• 106-41-2 4-bromo-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 2258-42-6 formyl acetic anhydride 
• 1122-91-4 4-bromo-benzaldehyde 
• 82825-32-9 4'-(4-Bromophenoxy)spirodioxetane> 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 5905-69-1 1-bromo-4-(difluoromethoxy)benzene 
• 5470-34-8 4-methoxyformanilide 
• 106-41-2 4-bromo-phenol 

Relevant articles and documents

Palladium-Catalyzed Carbonylative Synthesis of Aryl Formates under Mild Conditions

Aryl formates have been extensively applied as CO sources in CO-free carbonylation reactions. However, there are no catalytic synthetic procedures for their preparation. In this manuscript, we developed a convenient palladium-catalyzed procedure for the synthesis of aryl formates. Good yields were achieved under mild reaction conditions with formic acid as the formyl source. A formyl meeting: A convenient palladium-catalyzed carbonylation procedure for the synthesis of aryl formates is developed. Good yields are achieved under mild reaction conditions with formic acid as the formyl source.

Solvent- and catalyst-free N-formylations of amines at ambient condition: Exploring the usability of aromatic formates as N-formylating agents

A solvent- and catalyst-free N-formylation protocol has been developed for amines (1s–21s) where aromatic formates (1r–6r) were used as the N-formylating agents. The amine substrates include both primary and secondary aromatic amines (1s–19s) as well as aliphatic amine (20s) and a primary amide (21s). Structures of both the aromatic formate and amine components strongly influenced the rate of the reaction and yield of the N-formamide products. The reaction condition is mild and easy to operate. This protocol can be done smoothly under ambient conditions and gives high yield of formamide products. Furthermore, the present method cannot be applied for the formylation of thiol group (22s). This signifies its possible use for the chemoselective N-formylation of amine in the presence of thiol functionality.

Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

Difluoromethyl ethers are prepared from phenols in three steps via their respective formate ester derivatives. The formates are first converted to dichloromethyl ethers by treatment with PCl5. These ethers are then induced to undergo chlorine/fluorine exchange to form the respective difluoromethyl ethers. The chlorine/fluorine exchange is carried out by either a room temperature, solvolytic process using THF-5HF or Et3N-3HF as exchange medium, where HF is the ultimate source of fluorine, or by a direct displacement process in sulfolane at 125 C, where KF is the source of fluorine. By one or another of these processes, virtually all phenols, electron-rich and electron-poor, can be converted to their respective difluoromethyl ethers in good yields. Aliphatic alcohols are also able to be converted to their difluoromethyl ether derivatives using the Et3N-3HF exchange medium.