452929-54-3

Basic information

• Product Name: 4-BROMO-4'-CYANOBENZOPHENONE
• Synonyms: 4-BROMO-4'-CYANOBENZOPHENONE;4-(4-bromobenzoyl)benzonitrile
• CAS NO: 452929-54-3
• Molecular Formula: C₁₄H₈BrNO
• Molecular Weight: 286.12
• Mol File: 452929-54-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 425.4°C at 760 mmHg
• Flash Point: 211.1°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 1.92E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 4-BROMO-4'-CYANOBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-4'-CYANOBENZOPHENONE(452929-54-3)
• EPA Substance Registry System: 4-BROMO-4'-CYANOBENZOPHENONE(452929-54-3)

Safety Data

• Hazardous Substances Data: 452929-54-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H8BrNO/c15-13-7-5-12(6-8-13)14(17)11-3-1-10(9-16)2-4-11/h1-8H

Upstream product

• 3988-03-2 bis(4-bromophenyl)methanone 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 148651-39-2 (4-bromophenyl)zinc iodide 
• 1192164-35-4 4-(4-bromobenzyl)benzonitrile 

Relevant articles and documents

AIBN initiated functionalization of the benzylic sp3 C[sbnd]H and C[sbnd]C bonds in the presence of dioxygen

A sp3 C[sbnd]H bond functionalization and C[sbnd]C bond cleavage were realized by AIBN/O2 catalyst system, providing a series of benzophenones under mild reaction conditions. The mechanistic study shows that a peroxide intermediate is involved in this transformation, and in the case of diphenylmethanes, the sp3 C[sbnd]C bond is cleaved through the peroxide rearrangement, which might provides a new way to cleave relatively strong C[sbnd]C bond and be applied to more general C[sbnd]C bond activation.

L-proline-promoted Rosenmund-von Braun reaction

L-Proline was identified as an effective additive to promote the Rosenmund-von Braun reaction at a lower temperature (80-120°C). This modified Rosenmund-von Braun cyanation of aryl bromides exhibits excellent functional-group compatibility, and provide an efficient and convenient approach for the synthesis of aryl nitriles. Georg Thieme Verlag Stuttgart.