4537-05-7

Basic information

• Product Name: 1-methyl-2-(2-methylphenyl)sulfanyl-benzene
• Synonyms: Benzene, 1,1‘-thiobis[2-methyl-
• CAS NO: 4537-05-7
• Molecular Formula: C₁₄H₁₄S
• Molecular Weight: 214.331
• Mol File: 4537-05-7.mol
• Article Data: 29

Chemical Properties

• Melting Point: 64°C
• Boiling Point: 314.47°C (rough estimate)
• Density: 1.1151 (rough estimate)
• Refractive Index: 1.6170 (estimate)
• CAS DataBase Reference: 1-methyl-2-(2-methylphenyl)sulfanyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(2-methylphenyl)sulfanyl-benzene(4537-05-7)
• EPA Substance Registry System: 1-methyl-2-(2-methylphenyl)sulfanyl-benzene(4537-05-7)

Safety Data

• Hazardous Substances Data: 4537-05-7(Hazardous Substances Data)

Usage

Aromatic compound

Consists of a benzene ring
The structure of this compound includes a benzene ring, which is a six-carbon ring with alternating single and double bonds, giving it a characteristic aromatic stability.

Substituents

Methyl and 2-methylphenyl groups

The benzene ring has two attached groups

a methyl group (CH3) and a 2-methylphenyl group (a phenyl ring with a methyl group at the 2nd position).

Sulfur atom

Present in the structure
A sulfur atom is also part of the compound, which contributes to its strong odor and chemical reactivity.

Uses

Intermediate in organic synthesis and pharmaceuticals
1-methyl-2-(2-methylphenyl)sulfanyl-benzene is commonly used as an intermediate in the synthesis of various organic compounds and pharmaceuticals, making it an important building block in chemical manufacturing.

Strong odor

Known for its pungent smell
This chemical is known for its strong odor, which can be a potential irritant or hazard in certain concentrations.

Hazardous if not handled properly

Safety precautions required
Due to its potential hazards, it is important to take proper safety precautions when working with this compound, such as wearing appropriate protective equipment and handling it in a well-ventilated area.

Upstream product

• 95-53-4 o-toluidine 
• 615-37-2 ortho-methylphenyl iodide 
• 34878-60-9 sodium o-thiocresolate 
• 2093-46-1 2-methylphenyl diazonium tetrafluoroborate 
• 10387-40-3 potassium thioacetate 
• 4032-80-8 bis(2-methylphenyl)disulfide 
• 84383-79-9 bis(2-methylphenyl)iodonium tosylate 
• 95-48-7 ortho-cresol 
• 66107-34-4 2-methylphenyl triflate 
• 599-75-7 2-methylphenyl tosylate 
• 533-18-6 2-methylphenyl acetate 
• 62-55-5 thioacetamide 
• 16419-60-6 2-Methylphenylboronic acid 
• 137-06-4 2-thiocresol 

Downstream Products

• 5097-12-1 bis(2-methylphenyl) sulfone 
• 93012-55-6 2-(2-((6-carboxymethylphenyl)thio)phenyl)acetic acid 
• 1062600-55-8 1-(3-cyanopropyl)-2-((6-(3-cyanopropyl)phenyl)thio)benzene 
• 1062600-68-3 2-(2-((6-cyanomethylphenyl)thio)phenyl)acetonitrile 
• 5097-05-2 2,2′-sulfinylbis(methylbenzene) 
• 1207-12-1 4,6-dimethyldibenzothiophene 
• 32636-05-8 bis-(2-bromomethyl-phenyl)-sulfane 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Relevant articles and documents

Palladium Complex Immobilized on Magnetic Nanoparticles Modified with 2-Aminopyridine Ligand: A Novel and Efficient Recoverable Nanocatalyst for C–S and C–Se Coupling Reactions

A novel, versatile and efficient magnetically recoverable palladium nanocatalyst [Fe3O4@SiO2/2-aminopyridine-Pd(II)] was fabricated via the immobilization of palladium(II) complex on the surface of magnetic nanoparticles modified with 2-aminopyridine ligand. The structure of the as-fabricated Fe3O4@SiO2/2-aminopyridine-Pd(II) nanocomposite was characterized by a series of spectroscopic techniques including FT-IR, SEM, TEM, EDX, TGA, XRD, VSM and ICP-OES techniques. The Fe3O4@SiO2/2-aminopyridine-Pd(II) nanocomposite was utilized under mild and eco-friendly conditions in C–S and C–Se coupling reactions to afford a vast variety of diaryl sulfides and diaryl selenides with good to excellent yields. This heterogeneous palladium catalyst can be magnetically separated and reused for at least 7 consecutive trials without any reduction in activity. Graphical Abstract: [Figure not available: see fulltext.]

Heterogeneously Ni-Pd nanoparticle-catalyzed base-free formal C-S bond metathesis of thiols

This study rationally designed a heterogeneously catalyzed system (i.e., using Ni-Pd alloy nanoparticles supported on hydroxyapatite (Ni-Pd/HAP) under an H2atmosphere) achieving an efficient base-free formal C-S bond metathesis of various thiolsviasuppression of the Ni catalysis deactivation.

NiFe2O4 as a magnetically recoverable nanocatalyst for odourless C–S bond formation via the cleavage of C–O bond in the presence of S8 under mild and green conditions

We present green methodologies for one-pot and odourless syntheses of unsymmetric and symmetric diaryl sulfides via C─O bond activation using NiFe2O4 magnetic nanoparticles as a reusable heterogeneous nanocatalyst. The synthesis of unsymmetric sulfides is performed using the cross-coupling reaction of phenolic esters such as acetates, triflates and tosylates with arylboronic acid/S8 or triphenyltin chloride/S8 as thiolating agents in the presence of base and NiFe2O4 magnetic nanoparticles as a catalyst in poly(ethylene glycol) as solvent at 60–85°C. Also, the synthesis of symmetric diaryl sulfides from phenolic compounds using S8 as the sulfur source and NiFe2O4 as catalyst in dimethylformamide at 120°C is described. Using these protocols, the syntheses of various unsymmetric and symmetric sulfides become easier than using the available protocols due to the use of a magnetically reusable bimetallic nanocatalyst and avoiding the use of thiols and aryl halides.