4537-78-4 Usage
Description
1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt is a phosphatidylglycerol derivative with both phosphatidyl acyl groups being stearoyl. It is a significant component in the formulation of certain drug delivery systems, particularly liposomes, due to its unique structural properties and ability to encapsulate various therapeutic agents.
Uses
Used in Pharmaceutical Industry:
1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt is used as a component in the development of loposomal delivery systems for the controlled release of chemotherapeutic agents such as irinotecan and floxuridine in vivo. Its incorporation into these systems enhances the targeted delivery of drugs to cancer cells, improving their therapeutic efficacy and reducing systemic side effects.
Additionally, 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt is used as a key component in the encapsulation of anthracyclines, a class of potent antineoplastic drugs. By encapsulating these drugs within liposomes, the delivery system allows for a more precise targeting of tumors, reducing the risk of damage to healthy tissues and enhancing the overall treatment outcome for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 4537-78-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,3 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4537-78:
(6*4)+(5*5)+(4*3)+(3*7)+(2*7)+(1*8)=104
104 % 10 = 4
So 4537-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C42H83O10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39-40,43-44H,3-38H2,1-2H3,(H,47,48)
4537-78-4Relevant articles and documents
Synthesis and characterization of picket porphyrin receptors that bind phosphatidylglycerol, an anionic phospholipid found in bacterial membranes
Alliband, Amanda,Meece, Frederick A.,Jayasinghe, Champika,Burns, Dennis H.
, p. 356 - 362 (2013/02/26)
The lipid binding ability of four urea-picket porphyrins designed to bind to both the phosphate anion portion as well as the glycerol hydroxyl groups of phosphatidylglycerol (PG) has been investigated. Isothermal titration calorimetry (ITC) and 1H NMR were used to determine the receptor's stoichiometry of binding, association constants, and both the enthalpy and entropy of binding with the PG anion. Spectral evidence shows that the phosphate anion portion of PG is hydrogen bonded to the urea groups of the receptors. This binding interaction orients the PG anion in the receptor pocket such that its glycerol hydroxyl groups can align with a third urea picket, and results are furnished that suggest this multifunctional interaction does occur. The structure of the entire picket was found to influence the enthalpy and entropy of lipid binding. The synthesis of tetrabutlyammonium phosphatidylglycerol (TBAPG), and a detailed spectral characterization of its headgroup, is also presented.