4543-56-0

Basic information

• Product Name: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE
• Synonyms: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE;2-hydroxy-3-methyl-8-oxa-4-azabicyclo[4.3.0]nona-1,3,5-trien-7-one;5-Pyridoxolactone;5-pyridoxic acid lactone;7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one;Pyracin-5;Pyridoxic acid γ-lactone;3-Carboxy-4-(hydroxymethyl)-5-hydroxy-6-methylpyridine lactone
• CAS NO: 4543-56-0
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 4543-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 511.2°Cat760mmHg
• Flash Point: 263°C
• Appearance: /
• Density: 1.448g/cm³
• Vapor Pressure: 4.52E-11mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: ?20°C
• Solubility: Methanol
• CAS DataBase Reference: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(4543-56-0)
• EPA Substance Registry System: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(4543-56-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 4543-56-0(Hazardous Substances Data)

Usage

Description

2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE, also known as 5-Pyridoxolactone, is an organic compound that serves as an intermediate in the synthesis of analogues of Pyridoxine, a member of the B6 vitamin complex. It is found in various foodstuffs, including yeast, liver, and cereals, and plays a crucial role in the transport of protein Bsu1 and the uptake of thiamine (vitamin B1) through the characterization of the thiamine transporter Thi9 from Schizosaccharomyces pombe.

Uses

Used in Pharmaceutical Industry:
2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as an intermediate in the synthesis of Pyridoxine analogues for the development of pharmaceutical products targeting various health conditions. Its role in the transport of protein Bsu1 and thiamine uptake makes it a valuable component in the formulation of vitamin supplements and therapeutic agents.
Used in Nutritional Supplements:
In the nutritional supplement industry, 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as a precursor for the production of Pyridoxine, which is an essential component of B6 complex vitamins. These supplements help maintain optimal health and support various bodily functions, including the proper functioning of the nervous system and the synthesis of amino acids.
Used in Food Fortification:
2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as a fortifying agent in the food industry to enhance the nutritional value of food products. By incorporating this compound into food items, manufacturers can ensure that consumers receive an adequate amount of Pyridoxine and other essential nutrients, contributing to overall health and well-being.

Biochem/physiol Actions

5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.

InChI:InChI=1/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3

Upstream product

• 408314-50-1 7-amino-6-methyl-1H-furo[3,4-c]pyridin-3-one 
• 18872-74-7 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 105106-29-4 5-acetoxy-4-acetoxymethyl-6-methyl-nicotinic acid 
• 2027-66-9 3,4'-O-isopropylidene-5-pyridoxic acid 
• 94934-46-0 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carbonitrile 
• 2397-71-9 5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester 
• 65-23-6 5-hydroxy-6-methyl-3,4-pyridinedimethanol 
• 7472-18-6 6-Methyl-1H-furano<3,4-c>pyridine-3,4(5H)-dione 
• 89159-37-5 6-Methyl-7-nitro-1H-furano<3,4-c>pyridine-3,4(5H)-dione 
• 873965-95-8 4-chloro-6-methyl-7-nitro-1H-furo[3,4-c]pyridin-3-one 
• 60690-80-4 4-(acetoxymethyl)-5-(hydroxymethyl)-2-methylpyridin-3-yl acetate 
• 99768-47-5 (3-amino-5-aminomethyl-2-methyl-[4]pyridyl)-methanol; dihydrochloride 
• 17718-67-1 4-(ethoxymethyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 1136-52-3 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 

Downstream Products

• 1198621-47-4 C₁₆H₁₇FN₂O₃ 
• 1198621-48-5 C₃₂H₃₅FN₂O₃Si 

Relevant articles and documents

HIV INTEGRASE INHIBITORS FROM PYRIDOXINE

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HΙV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.

Chemistry of salicylic acid and anthranilic acid. I. Reduction of methyl salicylate, methyl anthranilate and their derivatives with sodium borohydride

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