454479-39-1

Basic information

• Product Name: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one
• Synonyms: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one
• CAS NO: 454479-39-1
• Molecular Weight: 421.542
• Mol File: 454479-39-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one(454479-39-1)
• EPA Substance Registry System: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one(454479-39-1)

Safety Data

• Hazardous Substances Data: 454479-39-1(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 

Downstream Products

• 171228-49-2 posaconazote 
• 170985-86-1 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 

Relevant articles and documents

Mono N-arylation of piperazine(III): Metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate

A novel application of Pd0-catalyzed arylation to mono N-arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N,N′-diarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N′-(4-aminophenyl)piperazine 5 as well as posaconazole 1 are described.