45498-20-2 Usage
Description
4-AMINOPYRIDINE-D6, also known as Dalfampridine D6, is a deuterated analog of the drug Dalfampridine. It is a compound that has been synthesized with six deuterium atoms incorporated into its structure, which can provide enhanced stability and sensitivity in various applications. 4-AMINOPYRIDINE-D6 is primarily used in scientific research and has potential therapeutic applications.
Uses
Used in Scientific Research:
4-AMINOPYRIDINE-D6 is used as a research tool for characterizing subtypes of potassium channels. Its deuterated nature allows for improved detection and analysis in experimental settings, making it a valuable asset in understanding the function and behavior of these channels.
Used in Pharmaceutical Development:
4-AMINOPYRIDINE-D6 serves as a precursor to the drug Pinacidil, which has potential therapeutic applications. The development of this compound can contribute to the advancement of treatments for various conditions.
Used in Multiple Sclerosis Management:
In its non-deuterated form, Dalfampridine has been used to manage some of the symptoms of multiple sclerosis. It is indicated for the symptomatic improvement of walking in adults with several variations of the disease, potentially improving their quality of life.
Check Digit Verification of cas no
The CAS Registry Mumber 45498-20-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,5,4,9 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 45498-20:
(7*4)+(6*5)+(5*4)+(4*9)+(3*8)+(2*2)+(1*0)=142
142 % 10 = 2
So 45498-20-2 is a valid CAS Registry Number.
45498-20-2Relevant articles and documents
General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C
Esaki, Hiroyoshi,Ito, Nobuhiro,Sakai, Shino,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
, p. 10954 - 10961 (2007/10/03)
A protocol of a versatile H-D exchange reaction of heterocyclic compounds catalyzed by heterogeneous Pd/C in D2O is described. The reaction of various nitrogen-containing heterocycles with 10% Pd/C (10 wt % of the substrate) under hydrogen atmosphere in D2O as a deuterium source at 110-180 °C for 24 h afforded the corresponding deuterated compounds with satisfactory efficiency of deuteration in moderate to excellent isolated yields. Furthermore, the Pd/C-H2-D2O system can be extended to the direct deuteration of biologically active compounds such as sulfamethazine, which is used as a synthetic antibacterial drug for fat stocks and would be applied as a general method for the preparation of the standard materials for the analysis of residual chemicals in foods and so on.
