455-15-2

Basic information

• Product Name: 4-FLUOROPHENYL METHYL SULFONE
• Synonyms: Sulfone, p-fluorophenyl methyl;4-FLUOROPHENYL METHYL SULPHONE;4-FLUOROPHENYL METHYL SULFONE;1-FLUORO-4-(METHYLSULFONYL)BENZENE;1-fluoro-4-(methylsulphonyl)benzene;4-Fluorophenylmethylsulfone,97%;4-Fluorobenzenesulfinic Acid Methyl Este;4-Fluorophenyl
• CAS NO: 455-15-2
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.19
• EINECS: 207-237-0
• Product Categories: Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 455-15-2.mol
• Article Data: 73

Chemical Properties

• Melting Point: 78-81 °C(lit.)
• Boiling Point: 95-97°C 7mm
• Flash Point: 132.8 °C
• Appearance: Almost white/Adhering Crystalline Powder
• Density: 1.2768 (estimate)
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
• BRN: 2045674
• CAS DataBase Reference: 4-FLUOROPHENYL METHYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)
• EPA Substance Registry System: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-15-2(Hazardous Substances Data)

Usage

Description

4-Fluorophenyl methyl sulfone is an organic compound characterized by its white solid appearance. It is a derivative of phenyl methyl sulfone with a fluorine atom substitution at the 4th position, which imparts unique chemical properties to the molecule.

Uses

Used in Pharmaceutical Industry:
4-Fluorophenyl methyl sulfone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
1. Preparation of Substituted Indazole Amides:
In the pharmaceutical industry, 4-Fluorophenyl methyl sulfone is used as a starting material for the preparation of substituted indazole amides. These compounds serve as glucokinase activators, which play a crucial role in regulating blood glucose levels and have potential applications in the treatment of type 2 diabetes.
2. Synthesis of 4-(4′-Trifluoromethoxyphenoxy)Phenyl Methyl Sulfone:
Another application of 4-Fluorophenyl methyl sulfone in the pharmaceutical industry is its use in the preparation of 4-(4′-trifluoromethoxyphenoxy)phenyl methyl sulfone. 4-FLUOROPHENYL METHYL SULFONE has potential applications in the development of new drugs targeting various diseases and conditions.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 371-15-3 p-fluorothioanisole 
• 124-63-0 methanesulfonyl chloride 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 14101-14-5 (4-fluorophenyl)trimethyltin 
• 7143-01-3 Methanesulfonic anhydride 
• 74-88-4 methyl iodide 
• 33599-22-3 (4-methanesulfonylphenyl)-N,N-dimethyl-amine 
• 371-42-6 4-Fluorothiophenol 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 1765-93-1 4-fluoroboronic acid 
• 20277-69-4 sodium methansulfinate 
• 153435-39-3 1-methanesulfonyl-4-(tributylstannyl)benzene 
• 164021-74-3 (1S,2R)-(-)-2-[N-(3’,5’-di-tert-butylsalicylidene)amino]-1,2-diphenylethanol 

Downstream Products

• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 
• 99902-90-6 4-(4'-methylphenyloxy)-phenyl methyl sulfone 
• 99902-91-7 C₁₃H₁₁ClO₃S 
• 99902-92-8 C₁₃H₁₁ClO₃S 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 75259-44-8 1-(4-Fluoro-benzenesulfonylmethyl)-cyclohexanol 
• 75259-28-8 1-(4-Chloro-phenyl)-2-(4-fluoro-benzenesulfonyl)-ethanol 
• 75259-41-5 2-[(4-fluorophenyl)sulfonyl]-1-phenylethan-1-ol 
• 75259-43-7 1-(4-Fluoro-benzenesulfonyl)-propan-2-ol 
• 75259-42-6 1-(4-Fluoro-benzenesulfonyl)-2-methyl-butan-2-ol 
• 286844-91-5 1-(methylsulfonyl)-4-(4'-(trifluoromethoxy)phenoxy)benzene 
• 90357-06-5 Bicalutamide 
• 228578-04-9 4-(4'-methylsulfonyl)phenoxyphenyl allyl ether 

Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

COVALENT ORGANIC FRAMEWORKS AND APPLICATIONS AS PHOTOCATALYSTS

Described herein are covalent organic frameworks. The covalent organic frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses. In one aspect, the covalent organic frameworks are composed of a plurality of fused aromatic groups and electron-deficient chromophores. The covalent organic frameworks are useful as photocatalysts in a number of different applications.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is