455279-96-6

Basic information

• Product Name: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide
• Synonyms: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide
• CAS NO: 455279-96-6
• Molecular Weight: 218.178
• Mol File: 455279-96-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide(455279-96-6)
• EPA Substance Registry System: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide(455279-96-6)

Safety Data

• Hazardous Substances Data: 455279-96-6(Hazardous Substances Data)

Upstream product

• 368-53-6 5-(trifluoromethyl)benzene-1,3-diamine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 641571-11-1 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 
• 955959-18-9 2-[3-(adamantan-1-ylsulfamoyl)-5-trifluoromethyl-phenylthiocarbamoyl]-2-cyano-acetamide 
• 955955-98-3 N-[3-(adamantan-1-ylsulfamoyl)-5-trifluoromethyl-phenyl]-acetamide 
• 955958-93-7 N-adamantan-1-yl-3-isothiocyanato-5-trifluoromethyl-benzenesulfonamide 
• 955957-00-3 N-adamantan-1-yl-3-amino-5-trifluoromethyl-benzenesulfonamide 
• 955938-65-5 3-acetylamino-5-trifluoromethyl-benzenesulfonyl chloride 

Relevant articles and documents

Method for synthesizing 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline

The invention relates to a method for synthesizing 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline, which comprises the following steps: 1, by using 3,5-diaminobenzotrifluoride as a raw material, carrying out protection to obtain a mono-substituted product and an intermediate byproduct; and 2, carrying out a cyclization reaction on the mono-substituted product, and carrying out deprotection to obtain the 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline. The synthesis process is safe and reliable, and has the advantages of low cost, easy control of reaction, simple post-treatment, economy, environmental protection and the like.

Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Isothiazole analogs were discovered as a novel class of active-site inhibitors of HCV NS5B polymerase. The best compound has an IC50 of 200 nM and EC50 of 100 nM, which is a significant improvement over the starting inhibitor (1). The X-ray complex structure of 1 with HCV NS5B was obtained at a resolution of 2.2 A, revealing that the inhibitor is covalently linked with Cys 366 of the 'primer-grip'. Furthermore, it makes considerable contacts with the C-terminus, β-loop, and more importantly, to the active-site of the enzyme. The uniqueness of this binding mode offers a new insight for the rational design of novel inhibitors for HCV NS5B polymerase.