4553-27-9

Basic information

• Product Name: 3-(4-Benzyl-piperazinyl)propanamine
• Synonyms: 3-(4-Benzyl-piperazinyl)propanamine;1-(3-Aminopropyl)-4-benzylpiperazine;4-Benzyl-1-(3-aminopropyl)piperazine;3-[4-(phenylmethyl)-1-piperazinyl]propan-1-amine;3-[4-(phenylmethyl)piperazin-1-yl]propan-1-amine
• CAS NO: 4553-27-9
• Molecular Formula: C₁₄H₂₃N₃
• Molecular Weight: 233.36
• Mol File: 4553-27-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 355.1 °C at 760 mmHg
• Flash Point: 166.1 °C
• Appearance: /
• Density: 1.038±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 3.19E-05mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 3-(4-Benzyl-piperazinyl)propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Benzyl-piperazinyl)propanamine(4553-27-9)
• EPA Substance Registry System: 3-(4-Benzyl-piperazinyl)propanamine(4553-27-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4553-27-9(Hazardous Substances Data)

Usage

General Description

3-(4-Benzyl-piperazinyl)propanamine is a chemical compound with a molecular formula C17H26N2. It is a derivative of propanamine and contains a piperazine ring with a benzyl group attached. 3-(4-Benzyl-piperazinyl)propanamine has potential pharmaceutical applications and may be used in the development of therapeutic drugs, particularly for neurological or psychopharmacological purposes. It is important to handle this compound with care and follow proper safety protocols, as it may have toxic or harmful effects if not used properly. Additional research and testing may be necessary to fully understand the potential uses and effects of 3-(4-Benzyl-piperazinyl)propanamine.

InChI:InChI=1/C14H23N3/c15-7-4-8-16-9-11-17(12-10-16)13-14-5-2-1-3-6-14/h1-3,5-6H,4,7-13,15H2

Upstream product

• 198478-03-4 3-(4-benzylpiperazin-1-yl) propanenitrile 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 1259172-46-7 N-(3-(4-benzylpiperazin-1-yl)propyl)cyclohexanecarboxamide 
• 1082288-31-0 N-(3-(piperazin-1-yl)propyl)cyclohexanecarboxamide 
• 1351411-90-9 N-(3-(4-(6-nitropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide 
• 1351410-70-2 ⁽¹⁸⁾F-N-(3-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)propyl)cyclohexanecarboxamide 

Relevant articles and documents

Synthesis of 2-(2-oxo-2H-chromen-4-yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions

Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04 ± 0.01 μM), noncompetitively inhibited AChE with a higher potency than tacrine and gala

RADIOLABELED COMPOUNDS AND METHODS THEREOF

The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.

A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers

A structure-activity relationship study of a series of novel Na+ channel blockers, structurally related to N-[3-(2,6-dimethyl-1-piperidinyl)propyl]- α-phenylbenzeneacetamide (1, PD85639) is described. The diphenylacetic acid portion of the molecule was left unchanged throughout the study, while structural features in the amine portion and the amide alkyl linkage of the molecule were modified. The compounds were tested for inhibition of veratridine-stimulated Na+ influx in CHO cells expressing type IIA Na+ channels. Several derivatives show a trend toward more potent Na+ channel blockade activity with increasing lipophilicity of the amine portion of the molecule. The presence of a phenyl ring near the amine increases inhibitory potency. A three-carbon spacer between the amide and amine is optimal, and a secondary amide linkage is preferred.