4559-87-9

Basic information

• Product Name: 1-Methyl-1-phenylurea
• Synonyms: (Methylphenylamino)formamide;1-Methyl-1-phenylurea
• CAS NO: 4559-87-9
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol File: 4559-87-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 257.6°C at 760 mmHg
• Flash Point: 109.6°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 0.0144mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-Methyl-1-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1-phenylurea(4559-87-9)
• EPA Substance Registry System: 1-Methyl-1-phenylurea(4559-87-9)

Safety Data

• Hazardous Substances Data: 4559-87-9(Hazardous Substances Data)

Usage

Physical Appearance

White crystalline solid.

Common Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals.

Stability

Stable under normal temperatures and pressures, not volatile.

Solubility

Low solubility in water, soluble in many organic solvents.

Health Hazards

May cause irritation to skin, eyes, and respiratory system.

Safety Precautions

Store and use in a well-ventilated area with appropriate protective equipment.

InChI:InChI=1/C8H10N2O/c1-10(8(9)11)7-5-3-2-4-6-7/h2-6H,1H3,(H2,9,11)

Upstream product

• 62-53-3 aniline 
• 27503-51-1 5-ethyl-1-methyl-3,5-diphenyl-barbituric acid 
• 590-28-3 potassium cyanate 
• 2739-12-0 N-methylaniline hydrochloride 
• 60-29-7 diethyl ether 
• 103-71-9 phenyl isocyanate 
• 74-89-5 methylamine 
• 624-83-9 methyl isocyanate 
• 57-13-6 urea 
• 556-89-8 nitrourea 
• 100-61-8 N-methylaniline 
• 18773-77-8 methyl(phenyl)cyanamide 
• 124-41-4 sodium methylate 
• 94398-07-9 3-Benzoyl-1-methyl-1-phenyl-urea 

Downstream Products

• 13866-64-3 N-methyl-N'-(4-nitro-phenyl)-urea 
• 2044-88-4 N-methyl-2,4-dinitroaniline 
• 1022-07-7 N-methylpicramide 
• 861521-72-4 N-methyl-N-nitro-N'-picryl-urea 
• 856352-27-7 N'-(2,4-dinitro-phenyl)-N-methyl-N-nitro-urea 
• 108-80-5 isocyanuric acid 
• 943-41-9 N-methyl-N-nitroso-4-nitroaniline 
• 479-45-8 tetryl 
• 140-22-7 1,5-diphenylcarbazide 
• 18773-77-8 methyl(phenyl)cyanamide 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 6716-39-8 3-methyl-1,5-diphenyl-imidazolidine-2,4-dione 
• 5841-17-8 3-methyl-5-phenyl-2-phenylimino-oxazolidin-4-one 
• 16698-03-6 N-nitro-N-methyl-4-nitroaniline 

Relevant articles and documents

An efficient hydration of cyanamides to substituted ureas with acetaldoxime as an effective water surrogate

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KINETICS AND MECHANISM OF METHANOLYSIS OF BENZOYL DERIVATIVES OF SUBSTITUTED PHENYLUREAS AND PHENYLTHIOUREAS

The methanolysis rate constants and dissociation constants have been measured of benzoyl derivatives of substituted phenylureas and phenylthioureas.The dissociation constants of the thio derivatives are higher by 1 order of magnitude and the rate constants are higher by 2 orders of magnitude than the respective values of the oxygen analogues.Logarithms of the rate and dissociation constants have been correlated with Hammett ? constant; the ρ constant of the methanolysis of the oxygen derivatives is almost 2 * higher than that of the thio derivatives, which is explained by a change in the rate-limiting step.Methylation of the phenyl nitrogen atom increases the acidity by almost 2 orders of magnitude.This effect is due obviously to steric hindrance to the conjugation with the adjacent carbonyl or thiocarbonyl group.

Some Extensions of von Braun (BrCN) Reaction on Organic Bases: Part II

Extensions of von Braun Cyanogen bromide reaction on Ephedra alkaloids and simpler bases have resulted in synthesis of substituted oxazolidines and a whole series of nitrogen analogues of ephedrine, desoxy ephedrine and simpler amines.The general applicability and limitations of such extension of the reaction are also discussed. - Key words: von Braun Cyanogen Bromide Reaction